Julia Laves, Melanie Wergin, Natali Bauer, Simon Franz Müller, Klaus Failing, Kathrin Büttner, Alina Hagen, Michaela Melzer, Michael Röcken
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The aim of this study was to compare the effect of Flunixin-Meglumin and Traumeel LT ad us. vet. on the acute phase response.</p><p><strong>Material and methods: </strong>A total of 60 stallions were recruited and 54 stallions entered the study with 27 stallions in each treatment group. The stallions were treated pre- and postoperatively with either Flunixin-Meglumin (FL) or with Traumeel LT ad us. vet. (TR). Blood was taken before and 24 h, 48 h and 72 h after castration. The following main parameters were assessed: SAA, fibrinogen, iron, white blood cells, neutrophils, Interleukin1ß, and cortisol. Wound healing and pain were assessed at 8 time points.</p><p><strong>Results: </strong>The main variable SAA was increased after surgery reaching a mean value of 122 µg/ml in the FL group and a mean SAA of 226 µg/ml in the TR group 48 h after surgery, reaching a significant difference only at the 24 h timepoint (<i>p</i> = 0.03). All stallions had the highest pain summary score 8 hours after surgery, with decreasing values thereafter. The pain scores were not statistically different at any time point. In the FL group five stallions developed a suture dehiscence compared to only one stallion in the TR group (<i>p</i> = 0.001).</p><p><strong>Discussion: </strong>Within the limitations of this study, Traumeel LT ad us. vet. seems to have proresolving effects on the inflammation induced by surgery making it a valuable treatment to reduce the APR induced by castration. Due to its different mode of action, Traumeel LT ad us. vet. might be an alternative treatment option if gastrointestinal side effects or renal side effects of NSAIDs should be avoided. Further studies are needed combining Traumeel LT ad us. vet. and Flunixin.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480072/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effect of Traumeel LT ad us. vet. on the perioperative inflammatory response after castration of stallions: a prospective, randomized, double-blinded study.\",\"authors\":\"Julia Laves, Melanie Wergin, Natali Bauer, Simon Franz Müller, Klaus Failing, Kathrin Büttner, Alina Hagen, Michaela Melzer, Michael Röcken\",\"doi\":\"10.3389/fvets.2024.1342345\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Stallion castration is a standard procedure with a risk of post-surgical complications. Castration induces an acute phase response (APR). Serum Amyloid-A (SAA) is a well-studied major acute phase protein (APP), that has been shown to be a good marker for the development of post-surgical complications. The current gold standard for reducing the APR after castration is Flunixin-Meglumin, which is a non-steroidal anti-inflammatory drug (NSAID) inhibiting COX1/2. In contrast, Traumeel LT ad us. vet. can modulate the APR by induction of the inflammation resolution. The aim of this study was to compare the effect of Flunixin-Meglumin and Traumeel LT ad us. vet. on the acute phase response.</p><p><strong>Material and methods: </strong>A total of 60 stallions were recruited and 54 stallions entered the study with 27 stallions in each treatment group. The stallions were treated pre- and postoperatively with either Flunixin-Meglumin (FL) or with Traumeel LT ad us. vet. (TR). Blood was taken before and 24 h, 48 h and 72 h after castration. 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引用次数: 0
摘要
简介种公马阉割是一项标准手术，存在术后并发症的风险。阉割会诱发急性期反应（APR）。血清淀粉样蛋白-A（SAA）是一种经过充分研究的主要急性期蛋白（APP），已被证明是手术后并发症发生的良好标志物。目前降低阉割后急性淀粉样蛋白APR的金标准是氟尼辛-美格列净，这是一种抑制COX1/2的非甾体抗炎药（NSAID）。相比之下，Traumeel LT ad us. vet.可通过诱导炎症消退来调节 APR。本研究旨在比较氟尼辛-美格鲁明和曲美LT ad us. vet.对急性期反应的影响：共招募了 60 匹种马，54 匹进入研究，每个治疗组 27 匹。种公马在术前和术后分别接受氟尼辛-美格鲁明（FL）或曲美LT（TR）治疗。阉割前、阉割后 24 小时、48 小时和 72 小时抽血。评估的主要参数如下SAA、纤维蛋白原、铁、白细胞、中性粒细胞、白细胞介素 1ß 和皮质醇。在8个时间点对伤口愈合和疼痛进行评估：主要变量 SAA 在手术后有所增加，FL 组的平均值为 122 微克/毫升，而 TR 组的平均值为 226 微克/毫升，仅在 24 小时的时间点上存在显著差异（p = 0.03）。所有种马在术后 8 小时的疼痛综合评分最高，之后评分逐渐降低。各时间点的疼痛评分均无统计学差异。FL 组有五匹种马出现缝合开裂，而 TR 组只有一匹种马出现缝合开裂（P = 0.001）：在本研究的局限性范围内，Traumeel LT ad us. vet.似乎对手术引起的炎症有缓解作用，因此是减少阉割引起的APR的一种有价值的治疗方法。由于其作用模式不同，如果要避免非甾体抗炎药的胃肠道副作用或肾脏副作用，Traumeel LT ad us. vet.还需要进一步研究将 Traumeel LT ad us.
The effect of Traumeel LT ad us. vet. on the perioperative inflammatory response after castration of stallions: a prospective, randomized, double-blinded study.
Introduction: Stallion castration is a standard procedure with a risk of post-surgical complications. Castration induces an acute phase response (APR). Serum Amyloid-A (SAA) is a well-studied major acute phase protein (APP), that has been shown to be a good marker for the development of post-surgical complications. The current gold standard for reducing the APR after castration is Flunixin-Meglumin, which is a non-steroidal anti-inflammatory drug (NSAID) inhibiting COX1/2. In contrast, Traumeel LT ad us. vet. can modulate the APR by induction of the inflammation resolution. The aim of this study was to compare the effect of Flunixin-Meglumin and Traumeel LT ad us. vet. on the acute phase response.
Material and methods: A total of 60 stallions were recruited and 54 stallions entered the study with 27 stallions in each treatment group. The stallions were treated pre- and postoperatively with either Flunixin-Meglumin (FL) or with Traumeel LT ad us. vet. (TR). Blood was taken before and 24 h, 48 h and 72 h after castration. The following main parameters were assessed: SAA, fibrinogen, iron, white blood cells, neutrophils, Interleukin1ß, and cortisol. Wound healing and pain were assessed at 8 time points.
Results: The main variable SAA was increased after surgery reaching a mean value of 122 µg/ml in the FL group and a mean SAA of 226 µg/ml in the TR group 48 h after surgery, reaching a significant difference only at the 24 h timepoint (p = 0.03). All stallions had the highest pain summary score 8 hours after surgery, with decreasing values thereafter. The pain scores were not statistically different at any time point. In the FL group five stallions developed a suture dehiscence compared to only one stallion in the TR group (p = 0.001).
Discussion: Within the limitations of this study, Traumeel LT ad us. vet. seems to have proresolving effects on the inflammation induced by surgery making it a valuable treatment to reduce the APR induced by castration. Due to its different mode of action, Traumeel LT ad us. vet. might be an alternative treatment option if gastrointestinal side effects or renal side effects of NSAIDs should be avoided. Further studies are needed combining Traumeel LT ad us. vet. and Flunixin.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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