人类内源性逆转录病毒和外源性病毒感染。

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1439292

Chenxuan Bao, Qing Gao, Huayuan Xiang, Yuxuan Shen, Qiaoqiao Chen, Qianqian Gao, Yuanfei Cao, Mengyu Zhang, Wenyuan He, Lingxiang Mao

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引用次数: 0

摘要

人类基因组中含有许多内源性逆转录病毒元件，即人类内源性逆转录病毒（HERVs），这些元件在进化过程中由于受到外源性逆转录病毒的感染而整合到基因组中。HERVs 占人类基因组的 8%，受宿主严格调控，与各种生理和病理过程有关。许多关于外源性病毒感染的研究都观察到 HERVs 的异常表达。在本综述中，我们将重点阐明 HERVs 在各种外源性病毒感染中的潜在作用，并进一步讨论其在抗病毒免疫中的意义。

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Human endogenous retroviruses and exogenous viral infections.

The human genome harbors many endogenous retroviral elements, known as human endogenous retroviruses (HERVs), which have been integrated into the genome during evolution due to infections by exogenous retroviruses. Accounting for up to 8% of the human genome, HERVs are tightly regulated by the host and are implicated in various physiological and pathological processes. Aberrant expression of HERVs has been observed in numerous studies on exogenous viral infections. In this review, we focus on elucidating the potential roles of HERVs during various exogenous viral infections and further discuss their implications in antiviral immunity.

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.