线粒体非能动功能与胚胎心脏发育

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1475603

Jingxian Shi, Yuxi Jin, Sha Lin, Xing Li, Donghui Zhang, Jinlin Wu, Yan Qi, Yifei Li

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引用次数: 0

摘要

胚胎期心脏的初始收缩需要大量能量供应，而这些能量主要来自线粒体功能。然而，在胚胎心脏发育过程中，线粒体的影响超出了能量补充的范围。越来越多的证据表明，线粒体通透性转换孔的打开和关闭、线粒体融合和分裂、有丝分裂吞噬、活性氧产生、细胞凋亡调节、钙离子平衡和细胞氧化还原状态在早期心脏发育中也起着至关重要的作用。因此，本综述旨在描述线粒体非能量功能在胚胎心脏发育中的重要作用。

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Mitochondrial non-energetic function and embryonic cardiac development.

The initial contraction of the heart during the embryonic stage necessitates a substantial energy supply, predominantly derived from mitochondrial function. However, during embryonic heart development, mitochondria influence beyond energy supplementation. Increasing evidence suggests that mitochondrial permeability transition pore opening and closing, mitochondrial fusion and fission, mitophagy, reactive oxygen species production, apoptosis regulation, Ca²⁺ homeostasis, and cellular redox state also play critical roles in early cardiac development. Therefore, this review aims to describe the essential roles of mitochondrial non-energetic function embryonic cardiac development.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.