体生长抑素类似物治疗神经内分泌肿瘤的现状和未来展望。

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY
Eleonora Lauricella, Sofija Vilisova, Nada Chaoul, Andrea Giglio, Gabriella D'Angelo, Camillo Porta, Mauro Cives
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引用次数: 0

摘要

简介:体生长抑素类似物(SSA)是作为抗分泌药物开发的,用于缓解功能性神经内分泌肿瘤(NET)患者的激素症状。其抗增生活性已在 PROMID 和 CLARINET 的三期试验中得到证实。目前,SSA 是大多数分化良好的 G1/G2 胃肠胰腺 NET 和肺 NET 的标准一线疗法:提供了现有SSA治疗NET临床应用的最新情况。专家观点:SSA是治疗NET的基石:SSA是治疗功能性和非功能性NET的基石。虽然标准剂量的SSA在分化良好的NET治疗方案中占有一席之地,但如何在治疗序列中最好地整合标签以上剂量的SSA仍存在不确定性,尤其是当肿瘤控制是治疗目标时。奥曲肽和兰瑞奥肽在临床上似乎可以互换,迄今为止尚未发现一种药物优于另一种药物的迹象。SSA是否可以在更激进的治疗后的维持治疗中加以利用,一线治疗后继续使用SSA是否是一种有效的治疗策略,新一代SSA(如帕司瑞奥肽)是否能克服已确立的SSA的耐药性,这些都是研究的关键领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The current status of somatostatin analogs in the treatment of neuroendocrine tumors and future perspectives.

Introduction: Somatostatin analogs (SSAs) were developed as antisecretory agents to palliate hormonal symptoms in patients with functioning neuroendocrine tumors (NETs). Their antiproliferative activity has been established in the phase 3 PROMID and CLARINET trials. SSAs currently represent the standard first-line therapy for the majority of well-differentiated G1/G2 gastroenteropancreatic NETs as well as for pulmonary NETs.

Areas covered: An update on the clinical applications of established SSAs for the treatment of NETs is provided. Perspectives on emerging nonpeptide SSAs such as paltusotine and innovative formulations of octreotide (CAM2029) are included.

Expert opinion: SSAs represent the cornerstone of treatment for both functioning and nonfunctioning NETs. While standard-dose SSAs have a defined place in the therapeutic algorithm of well-differentiated NETs, uncertainties remain on how to best integrate above-label doses of SSAs in the treatment sequence, particularly when tumor control is the goal. Octreotide and lanreotide appear to be clinically interchangeable, and no signs of superiority of one agent over the other has been observed so far. Whether SSAs may be exploited in the maintenance setting following more aggressive treatments, whether continuing SSAs beyond-progression after first-line therapy could be an effective treatment strategy, and whether new-generation SSAs such as pasireotide could overcome resistance to established SSAs are key areas of investigation.

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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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