Aculeaquamides B 和 C，两种新的对位喹酰胺，来自黑曲霉 WHUF0198 和青霉 DM27 的共培养。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-10-18 DOI:10.1016/j.fitote.2024.106251

Philomina Panin Edjah , Mao-Fang Lu , Wei-Chen Chen , Jun Wu , Yu-Ting Zhong , Mu Li , Qi Chen , Kong-Kai Zhu , Rui-Ying Yuan , Wei-Xin Tao , Ke-Jia Wu , You-Sheng Cai

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引用次数: 0

摘要

从海洋真菌Aspergillus aculeatinus WHUF0198和红树林相关真菌Penicillium sp.DM27的共培养物中分离出两种新的对位喹酰胺（PHQs），即aculeaquamides B和C（1和2），以及四种已知的PHQs（3-6）。化合物 1 是首个 PHQ 衍生物，具有不常见的 7/6/5/5/6/5 六环体系。根据详尽的核磁共振光谱测量和 HRESIMS 数据，阐明了分离化合物的结构。通过 TDDFT-ECD 计算确定了新化合物的绝对构型。化合物 3 抑制了 AngII 诱导的心脏肥大，同时表现出相对较低的心肌细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Aculeaquamides B and C, two new paraherquamides from the co-culture of Aspergillus aculeatinus WHUF0198 and Penicillium sp. DM27

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Aculeaquamides B and C, two new paraherquamides from the co-culture of Aspergillus aculeatinus WHUF0198 and Penicillium sp. DM27

Two new paraherquamides (PHQs) namely aculeaquamides B and C (1 and 2), along with four known PHQs (3–6), were isolated from the co-culture of marine fungus Aspergillus aculeatinus WHUF0198 and mangrove-associated fungus Penicillium sp. DM27. Compound 1 represents the first PHQ derivative featuring an uncommon 7/6/5/5/6/5 hexacyclic system. The structures of the isolated compounds were elucidated based on exhaustive NMR spectroscopy measurement and HRESIMS data. The absolute configurations of new compounds were determined by TDDFT-ECD calculations. Compound 3 demonstrated suppression of AngII-induced cardiac hypertrophy while exhibiting relatively low cardiomyocyte toxicity.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.