干扰素λ受体1变体的表达和功能。

IF 3.5 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2024-10-22 DOI:10.1002/1873-3468.15041

Laura A Novotny, Eric G Meissner

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引用次数: 0

摘要

λ干扰素（IFNL）是宿主抵御粘膜表面病原体的重要防御因子。在人体中，IFNL 信号部分受λ干扰素受体 1 蛋白的低表达和细胞类型限制的调节，其表达主要限于粘膜表面的上皮细胞。本综述将研究表明 IFNLR1 转录变体在介导细胞对 IFNL 配体暴露的反应和调节通路活性方面发挥作用的证据。

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Expression and function of interferon lambda receptor 1 variants.

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.