炎症性肠病中的免疫代谢和线粒体:治疗干预的作用?

IF 4 3区 医学 Q2 CELL BIOLOGY
Disease Models & Mechanisms Pub Date : 2024-10-01 Epub Date: 2024-10-17 DOI:10.1242/dmm.050895
Claire E Adams, Duncan G Rutherford, Gareth R Jones, Gwo-Tzer Ho
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引用次数: 0

摘要

炎症性肠病(IBD)是一种常见的不治之症,其特征是反复发作的免疫介导的肠道炎症和病因不明的损伤。目前的先进疗法以关键的白细胞贩运和细胞因子信号枢纽为目标,但仅对 50% 的患者有效。随着 IBD 线粒体功能障碍的证据越来越多,以及我们对新陈代谢在炎症中的作用的认识不断进步,我们将概述 IBD 治疗的新型新陈代谢方法,挑战当前的 "治疗上限",确定干预的关键途径,并重新认识 21 世纪的新陈代谢生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunometabolism and mitochondria in inflammatory bowel disease: a role for therapeutic intervention?

Inflammatory bowel diseases (IBDs), incurable conditions characterised by recurrent episodes of immune-mediated gut inflammation and damage of unknown aetiology, are common. Current advanced therapies target key leukocyte-trafficking and cytokine-signalling hubs but are only effective in 50% of patients. With growing evidence of mitochondrial dysfunction in IBD and advances in our understanding of the role of metabolism in inflammation, we provide an overview of novel metabolic approaches to IBD therapy, challenging the current 'therapeutic ceiling', identifying critical pathways for intervention and re-imagining metabolic biomarkers for the 21st century.

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来源期刊
Disease Models & Mechanisms
Disease Models & Mechanisms 医学-病理学
CiteScore
6.60
自引率
7.00%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
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