在一名库欣综合征患者中，通过手术切除产生肾上腺皮质激素的肺类癌，逆转了基底节高代谢：概念验证。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI:10.1097/RLU.0000000000005531

Gaurav Malhotra, Rajeev Kasaliwal, Karishma Rupani, Anurag R Lila, Trupti Upadhye, Tushar Bandgar, Nalini S Shah

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引用次数: 0

摘要

摘要：一名 34 岁的女性患者因严重精神病和库欣综合征的临床特征接受了 18F-FDG PET/CT 检查，结果显示其肺部病变和双侧基底节主要代谢增加，这与急性精神病的闪烁成像相关。病灶经手术切除，组织病理学证实为促肾上腺皮质激素分泌型肺类癌。治疗后的18F-FDG正电子发射计算机断层扫描显示，大脑新陈代谢恢复正常，精神病完全逆转。尽管罕见，但我们仍应注意将精神病作为库欣综合征的首发症状，并使用18F-FDG PET/CT绘制脑代谢图，如本病例所示。

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Reversal of Basal Ganglia Hypermetabolism Following Surgical Removal of Adrenocorticotropic Hormone-Producing Lung Carcinoid in a Patient of Cushing Syndrome With Unusual Presentation of Acute Psychosis: Proof of Concept.

Abstract: A 34-year-old woman who presented with severe psychosis and clinical features of Cushing syndrome underwent 18 F-FDG PET/CT that revealed hypermetabolic lung lesion along with predominantly increased metabolism of bilateral basal ganglia, a scintigraphic correlate of acute psychosis. The lesion was surgically excised and histopathologically proven to be adrenocorticotropic hormone-producing lung carcinoid. Posttreatment 18 F-FDG PET scan showed restoration of normal brain metabolism with complete reversal of psychosis. Even though rare, one should be aware of psychosis as an initial presentation of Cushing syndrome and use of 18 F-FDG PET/CT for mapping brain metabolism as shown in this case.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.