巴西成人健康纵向研究（ELSA-Brazil）中按性别分列的消极生活事件和抑郁症。

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.1016/j.clinsp.2024.100488

Simone V Silva, Itamar S Santos, Danielle B Lima, Alessandra C Goulart, Ana C Varella, Paulo A Lotufo, Andre R Brunoni, Isabela M Bensenor

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引用次数: 0

摘要

目的性别差异可能会干扰消极生活事件（NLEs）与抑郁症患病率/发病率之间的关联。本研究利用 ELSA 巴西队列的数据评估了性别在这种关联中的影响：作者分析了 15,088 名参与者（平均年龄 52.1 (9.1)，54.4% 为女性）。基线访问了非传染性疾病（抢劫、住院、近亲死亡、经济困难和爱情关系破裂）。抑郁情况在基线和随访时进行评估。作者建立了逻辑回归模型（比率 [OR]，95 % 置信区间 [95 % CI]）和泊松回归模型（相对风险 [RR]，[95 % CI]）来评估这种关联：结果：与男性相比，女性报告的非传染性疾病更多。作者发现 NLE 与抑郁症发病率之间存在关联：对于男性而言，住院（OR = 1.83；95 % CI 1.16-2.91）、经济困难（OR = 2.42；95 % CI 1.69-3.49）、爱情关系破裂（OR = 2.54；95 % CI 1.50-4.29）和任何 NLE（OR = 2.30；95 % CI 1.59-3.35）；对于女性而言，抢劫（OR = 1.81；95 % CI 1.31-2.49）、住院（OR = 1.46；95 % CI 1.11-1.92）、经济困难（OR = 1.76；95 % CI 1.43-2.17）、爱情关系破裂（OR = 1.66；95 % CI 1.20-2.32）和任何 NLE（OR = 1.65；95 % CI 1.34-2.04）。对于男性而言，只有经济困难（RR = 2.09；95 % CI 1.55-2.83）与抑郁症相关，而对于女性而言，抢劫（RR = 1.54；95 % CI 1.16-2.04）、住院（RR = 1.36；95 % CI 1.07-1.74）、经济困难（RR = 1.37；95 % CI 1.14-1.65）和任何 NLE（RR = 1.25；95 % CI 1.04-1.49）与抑郁症相关。近亲死亡与抑郁症患病率/发病率之间没有关联：结论：男性和女性的非传染性疾病都与抑郁症有关，对后者的影响更大。

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Negative life events and depression by gender in the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil).

Objective: Gender differences may interfere with the association between Negative Life Events (NLEs) and prevalent/incident depression. This study evaluated the effect of gender in this association using data from the ELSA-Brazil cohort.

Methods: The authors analyzed 15,088 participants (mean age, 52.1 (9.1), 54.4 % women). NLEs (robbery, hospitalization, death of a close relative, financial hardship, and rupture of a love relationship) were accessed at baseline. Depression was assessed at baseline and follow-ups. The authors built logistic (Odds Ratio [OR], 95 % Confidence Interval [95 % CI]) and Poisson regression models (Relative Risk [RR], [95 % CI]) to evaluate this association.

Results: Women reported more NLEs compared to men. The authors found associations between NLEs and prevalent depression: for men, hospitalization (OR = 1.83; 95 % CI 1.16‒2.91), financial hardship (OR = 2.42; 95 % CI 1.69‒3.49), rupture of a love relationship (OR = 2.54; 95 % CI 1.50‒4.29), and any NLE (OR = 2.30; 95 % CI 1.59‒3.35); and for women, robbery (OR = 1.81; 95 % CI 1.31‒2.49), hospitalization (OR = 1.46; 95 % CI 1.11‒1.92), financial hardship (OR = 1.76; 95 % CI 1.43‒2.17), rupture of a love relationship (OR = 1.66; 95 % CI 1.20‒2.32), and any NLE (OR = 1.65; 95 % CI 1.34‒2.04). For incident depression only financial hardship (RR = 2.09; 95 % CI 1.55‒2.83) was associated with depression in men, while, for women, robbery (RR = 1.54; 95 % CI 1.16‒2.04); hospitalization (RR = 1.36; 95 % CI 1.07‒1.74), financial hardship (RR = 1.37; 95 % CI 1.14‒1.65), and any NLE (RR = 1.25; 95 % CI 1.04‒1.49) were associated with incident depression. No association was found between the death of a close relative and prevalent/incident depression.

Conclusion: NLEs were associated with depression in men and women, with a higher impact in the latter.

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.