遗传性乳腺癌和卵巢癌的级联基因检测接受率：系统回顾与元分析》。

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI:10.1097/GRF.0000000000000895

Muhammad Danyal Ahsan, Isabelle R Chandler, Samantha Min, Benjamin Grant, Michelle Primiano, Jamieson Greenwald, Tamar N Soussana, Becky Baltich Nelson, Charlene Thomas, Eloise Chapman-Davis, Ravi N Sharaf, Melissa K Frey

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引用次数: 0

摘要

这是一项系统综述和荟萃分析，评估了遗传性乳腺癌和卵巢癌综合征级联基因检测的接受率。在纳入荟萃分析的 30 项研究中，级联基因检测的接受率为 33%（95% CI 25%-42%），女性亲属的接受率高于男性亲属，一级亲属的接受率高于二级亲属。这些研究结果表明，遗传性乳腺癌和卵巢癌综合征高危人群对级联基因检测的接受度不高，错失了癌症预防和早期检测的良机。有必要采取干预措施来提高接受率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Uptake of Cascade Genetic Testing for Hereditary Breast and Ovarian Cancer: A Systematic Review and Meta-Analysis.

This is a systematic review and meta-analysis evaluating the uptake of cascade genetic testing for hereditary breast and ovarian cancer syndrome. Among 30 studies included for meta-analysis, the uptake of cascade genetic testing was 33% (95% CI 25%-42%), with higher uptake rates among females compared with male relatives, and among first-degree compared with second-degree relatives. These findings indicate suboptimal uptake of cascade genetic testing among people at risk for hereditary breast and ovarian cancer syndrome, representing a missed opportunity for cancer prevention and early detection. There is a need for interventions to improve uptake rates.

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来源期刊

Clinical obstetrics and gynecology 医学-妇产科学

CiteScore

2.70

自引率

0.00%

发文量

186

审稿时长

3 months

期刊介绍： Each issue of Clinical Obstetrics and Gynecology is a complete symposium on one or two timely topics of interest in obstetrics and gynecology. For each quarterly issue, two prominent guest editors solicit contributions on key clinical topics of interest to practicing physicians. Procedures, current clinical problems, medical and surgical treatments, and effective diagnostic aids are all carefully reviewed in original articles. The result is an instructive resource that dispenses trustworthy clinical guidance that enhances your understanding of key areas of your practice.