过渡金属催化的 8-甲基喹啉的 C-H 活化/官能化。

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical record Pub Date : 2024-11-01 Epub Date: 2024-10-18 DOI:10.1002/tcr.202400116

Fatemeh Doraghi, Mohammad Mahdi Aghanour Ashtiani, Mahmoud Ameli, Bagher Larijani, Mohammad Mahdavi

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引用次数: 0

摘要

8 甲基喹啉被认为是参与多种 C（sp3）-H 官能化反应的理想底物。螯合氮原子的存在使 8-甲基喹啉很容易与各种过渡金属形成环金属络合物，从而导致功能化喹啉的选择性合成。考虑到喹啉核在药物化学中的重要性，我们在这篇综述文章中介绍了近十年来在过渡金属催化下与 8-甲基喹啉的 C-H 活化和官能化有关的文献。

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Transition Metal-Catalyzed C-H Activation/Functionalization of 8-Methylquinolines.

8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp³)-H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C-H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade.

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.