钯催化未活化烯的位点和区域选择性还原赫克加氢反应研究。

IF 1.5 4区 医学 Q4 CHEMISTRY, MEDICINAL
Takahiro Shirai, Ryo Nakajima, Takuya Kumamoto
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引用次数: 0

摘要

我们研究了使用钯催化剂和氢硅烷进行还原性 Heck 加氢反应的反应路径。验证反应机理的一个关键问题是,Ar-PdII-I 或 Si-PdII-H,哪种活性物质首先对烯进行迁移插入。确定这一步骤对于阐明反应机理至关重要。为此,我们设计了一种含有两个三取代烯烃的底物,并对其产物进行了测试。结果表明,Ar-PdII-I 向烯的迁移插入是反应的初始步骤。此外,该反应还能构建一个四碳中心,并以较高的官能团耐受性获得高产率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of Palladium-Catalyzed Site and Regioselective Reductive Heck Hydroarylation of Unactivated Alkene.

We studied the reaction pathway of our reductive Heck hydroarylation using a palladium catalyst and a hydrosilane. A key question to verify the reaction mechanism was which active species, Ar-PdII-I or Si-PdII-H, first performs migratory insertion into the alkenes. Identifying this step is crucial to elucidate the reaction mechanism. To address this, we designed a substrate containing two trisubstituted alkenes and tested its product. The results suggest that the migratory insertion of Ar-PdII-I into the alkene is the initial step of the reaction. Furthermore, this reaction can construct a quaternary carbon center and give high yields with high functional group tolerance.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
132
审稿时长
1.7 months
期刊介绍: The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.
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