青春期和成年早期的体育锻炼与 40 岁前患乳腺癌的风险。

IF 3.7 3区 医学 Q2 ONCOLOGY
Rebecca D Kehm, Jeanine M Genkinger, Julia A Knight, Robert J Maclnnis, Yuyan Liao, Shuai Li, Prue C Weideman, Wendy K Chung, Allison W Kurian, Sarah V Colonna, Irene L Andrulis, Saundra S Buys, Mary B Daly, Esther M John, John L Hopper, Mary Beth Terry
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引用次数: 0

摘要

背景:乳腺癌(BC)发病率在 40 岁以下女性中呈上升趋势,这说明有必要对年轻女性的乳腺癌风险因素进行研究:我们利用一个国际家庭队列(n=26,348)的数据,研究青春期和成年早期的娱乐性体育活动(RPA)是否与 40 岁前的乳腺癌风险有关。该队列包括 2,502 名在 40 岁前确诊患有乳腺癌的女性,其中 2,408 名在研究注册前确诊(68% 在注册后 5 年内)。女性报告了她们在青春期(12-17 岁)和成年早期(25-34 岁)每周中等强度和剧烈强度 RPA 的平均小时数,这些小时数被转换为每周经年龄调整的总代谢当量,并分为四等分。我们使用根据研究中心、种族和民族以及教育程度进行调整的 Cox 比例危险回归模型,对 40 岁(随访时间从 18 岁开始)之前的达到年龄进行了分析:在青春期和成年早期,RPA处于最高四分位数与最低四分位数分别与40岁前 BC风险降低12%[HR (95% CI):0.88 (0.78, 0.98)]和16%[HR (95% CI):0.84 (0.74, 0.95)]有关。在青春期和成年早期均处于RPA最高四分位数(Pearson correlation=0.52)与两个时间点均不处于RPA最高四分位数相比,风险降低22%[HR(95% CI):0.78 (0.68, 0.89)]:研究结果表明,青春期和成年早期的 RPA 可降低 40 岁前的 BC 风险:影响:促进青春期和成年早期体育锻炼的政策可能对减轻年轻女性日益加重的乳腺癌负担非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years.

Background: Breast cancer (BC) incidence is increasing in women under age 40 years, underscoring the need for research on BC risk factors for younger women.

Methods: We used data from an international family cohort (n=26,348) to examine whether recreational physical activity (RPA) during adolescence and early adulthood are associated with BC risk before age 40. The cohort includes 2,502 women diagnosed with BC before age 40, including 2,408 diagnosed before study enrollment (68% within 5 years of enrollment). Women reported their average hours-per-week of moderate and strenuous RPA during adolescence (12-17 years) and early adulthood (25-34 years), which were converted to total age-adjusted metabolic equivalents-per-week and categorized into quartiles. We conducted attained age analyses until age 40 (follow-up time began at age 18) using Cox proportional hazards regression models adjusted for study center, race and ethnicity, and education.

Results: Being in the highest versus lowest quartile of RPA during adolescence and early adulthood were respectively associated with 12% [HR (95% CI): 0.88 (0.78, 0.98)] and 16% [HR (95% CI): 0.84 (0.74, 0.95) lower BC risks before age 40. Being in the highest quartile of RPA during both adolescence and early adulthood (Pearson correlation=0.52) versus neither timepoint was associated with a 22% lower risk [HR (95% CI): 0.78 (0.68, 0.89)].

Conclusions: Findings suggest that RPA during adolescence and early adulthood may lower BC risk before age 40.

Impact: Policies promoting physical activity during adolescence and early adulthood may be important for reducing the growing burden of breast cancer in younger women.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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