胰岛素抵抗、肥胖和生活方式与青少年患高尿酸血症风险的关系。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Linyan Cheng, Jinhu Zhou, Ying Zhao, Na Wang, Minya Jin, Wen Mao, Guangjun Zhu, Donglian Wang, Junbo Liang, Bo Shen, Yufen Zheng
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引用次数: 0

摘要

背景:高尿酸血症是肥胖儿童和青少年的常见病,与胰岛素抵抗密切相关。本研究旨在探讨青少年胰岛素抵抗和高尿酸血症之间的关系,以及它们与青少年生活方式因素之间的关系,为青少年高尿酸血症的风险因素提供早期指导:这项研究包括 233 名 10 至 20 岁的青少年。胰岛素抵抗通过稳态模型评估-胰岛素抵抗(HOMA-IR)法进行评估。二元逻辑回归分析用于评估 HOMA-IR 与高尿酸血症状态和血清尿酸 (UA) 水平之间的关联。随后,参与者被分为两组,即非胰岛素抵抗组(HOMA-IR ≤ 3.2)和胰岛素抵抗组(HOMA-IR > 3.2),以进一步探讨可能影响血清尿酸水平的因素。最后,通过 ROC 曲线评估了不同指标对高尿酸血症的预测能力:二元逻辑回归分析表明,HOMA-IR 升高的人患高尿酸血症的风险显著增加(p 结论:HOMA-IR 是预测高尿酸血症的指标之一:HOMA-IR被认为是高尿酸血症发生的独立风险因素,可作为预测青少年高尿酸血症发生的敏感指标。建议患有高尿酸血症的胰岛素抵抗青少年保持正常体重、每周进行 1-3 小时的体育锻炼、避免熬夜和限制含糖饮料的摄入量,以降低青少年高尿酸血症的发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The associations of insulin resistance, obesity, and lifestyle with the risk of developing hyperuricaemia in adolescents.

Background: Hyperuricaemia is common among obese children and adolescents, and is closely related to insulin resistance. The aim of this study was to explore the relationships between youth insulin resistance and hyperuricaemia, as well as their relationships with lifestyle factors in youths, to provide early guidance on the risk factors for hyperuricaemia in adolescents.

Methods: This study included 233 adolescents aged 10 to 20 years. Insulin resistance was evaluated via the homeostasis model assessment-insulin resistance (HOMA-IR) method. Binary logistic regression analysis was used to assess the associations of HOMA-IR with hyperuricaemia status and serum uric acid (UA) levels. The participants were subsequently divided into two groups, the noninsulin resistant group (HOMA-IR ≤ 3.2) and the insulin resistant group (HOMA-IR > 3.2), to further explore the factors that may affect the serum UA level. Finally, the predictive ability of different indicators of hyperuricaemia was evaluated via the ROC curve.

Results: Binary logistic regression analysis revealed a significant increase in the risk of developing hyperuricaemia for individuals with elevated HOMA-IR (p < 0.001) and insulin resistance (p < 0.01). Spearman's correlation analysis revealed a significant positive linear correlation between HOMA-IR and serum UA levels (r = 0.4652, p < 0.001). Among insulin-resistant adolescents, UA levels were positively correlated with weight ratings, frequency of staying up late, and sugary beverages intake. Notably, individuals who engaged in 1-3 h of weekly exercise had the lowest UA levels. The area under the ROC curve for HOMA-IR was 0.847 (cut-off value = 2.165, p < 0.001), and the optimal prediction model included HOMA-IR, BMI z-score, and other lifestyle factors (AUC: 0.870, p < 0.001)).

Conclusion: HOMA-IR was identified as an independent risk factor for the development of hyperuricaemia and could be used as a sensitive indicator for the prediction its development in adolescents. In insulin-resistant adolescents with hyperuricaemia, maintaining normal weight, engaging in physical exercise for 1-3 h per week, avoiding staying up late and limiting sugary beverages intake are recommended to reduce the prevalence of hyperuricaemia among adolescents.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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