甘油三酯血糖指数与痛风之间的关系:基于 2007-2018 年国家健康调查的横断面分析。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Yahui Dai, Yushan Zhang, Bo Wang, Lei Cao, Zhiyuan Wang
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引用次数: 0

摘要

背景:甘油三酯血糖(TyG)指数的定义为 Ln [空腹甘油三酯(毫克/分升)×空腹血糖(毫克/分升)/2],该指数有助于了解整体代谢状况。然而,TyG 指数与痛风之间的关系尚未得到研究。因此,本研究探讨了 TyG 指数与痛风之间的相关性:本研究利用 2007 年至 2018 年进行的美国国家健康与营养调查的数据,调查了 TyG 指数与痛风之间的关系。对连续数据采用t检验,对分类数据采用卡方检验,对人口统计学数据和潜在风险因素进行了分析和比较。为研究TyG指数与痛风之间的关系,还进行了逻辑回归和亚组分析:共有 14,924 人参加了研究,其中 726 人(4.86%)被诊断为痛风。在未控制任何协变量的情况下,观察到TyG指数升高与痛风风险增加之间存在显著的正相关性,赔率(OR)为2.07,95%置信区间(CI)为1.76至2.43。经过全面调整后,这种关联仍具有显著的统计学意义,调整后的 OR 为 1.43,95% 置信区间为 1.14 至 1.80。亚组分析显示了显著的交互作用,尤其是女性(OR = 2.55;95% CI:2.00-3.26)、无服兵役史者(OR = 2.15;95% CI:1.66-2.43)和无糖尿病者(OR = 2.00;95% CI:1.64-2.43):结论:TyG指数与痛风之间存在正相关。因此,有必要进一步开展大规模前瞻性研究,以全面分析 TyG 指数在痛风中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association between triglyceride glucose index and gout: a cross-sectional analysis based on NHANES 2007-2018.

Background: The triglyceride glucose (TyG) index, defined as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2], provides insights into overall metabolic status. However, the association between the TyG index and gout has not been investigated. Therefore, this study explored the correlation between the TyG index and gout.

Methods: Using data from the National Health and Nutrition Examination Survey, which was conducted from 2007 to 2018, this study investigated the relationship between the TyG index and gout. Demographic data and potential risk factors were analyzed and compared using t tests for continuous data and chi-square tests for categorical data. Logistic regression and subgroup analysis were performed to examine the association between the TyG index and gout.

Results: A total of 14,924 participants were enrolled, among whom 726 (4.86%) were diagnosed with gout. Without controlling for any covariates, a significant positive correlation was observed between an elevated TyG index and increased risk of gout, with an odds ratio (OR) of 2.07 and a 95% confidence interval (CI) ranging from 1.76 to 2.43. After full adjustment, this association remained statistically significant, with an adjusted OR of 1.43 and a 95% CI from 1.14 to 1.80. Subgroup analyses revealed significant interactions, particularly for females (OR = 2.55; 95% CI: 2.00-3.26), individuals with no military service history (OR = 2.15; 95% CI: 1.66-2.43), and those without diabetes (OR = 2.00; 95% CI: 1.64-2.43).

Conclusion: A positive correlation was observed between the TyG index and gout. Consequently, further large-scale prospective studies are warranted for a comprehensive analysis of the role of the TyG index in gout.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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