抑郁症青少年对负面情绪刺激的 P300 振幅变化与舍曲林的治疗反应相关。

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2024-10-11 DOI:10.1016/j.brainres.2024.149272

Lin Zhao , Dongdong Zhou , Xiaoqing He , Xinyu Peng , Jinhui Hu , Lingli Ma , Xinyi Liu , Wanqing Tao , Ran Chen , Zhenghao Jiang , Chenyu Zhang , Jing Liao , Jiaojiao Xiang , Qi Zeng , Linqi Dai , Qi Zhang , Su Hong , Wo Wang , Li Kuang

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引用次数: 0

摘要

目的：青少年抑郁症的特点是复发率高、功能受损严重，而且与自杀风险密切相关。抗抑郁药是治疗抑郁症的常用处方药，但很少有可重复的神经生物学标志物能反映抑郁症和抗抑郁药治疗反应。因此，发现一种稳定可靠的神经生物学标志物对于青少年抑郁症的临床诊断和治疗都具有重要价值：方法：招募 107 名重度抑郁症患者（MDD 组，男性 30 人，女性 77 人，平均年龄 14.80 岁）和 25 名健康受试者（HC 组，男性 13 人，女性 12 人，平均年龄 15.72 岁），让他们完成一项与负面情绪线索相关的二选一奇异任务。所有参与者都填写了一份自填问卷，以收集人口统计学信息。一名训练有素的精神科医生采用汉密尔顿抑郁量表（HAMD-17）来评估抑郁的严重程度。在 107 名患有抑郁症的青少年中，61 人接受了为期 8 周的抗抑郁药物治疗，其中 61 人接受了随访。使用 Curry 8 系统通过 64 个头皮电极连续记录多通道脑电图。使用 MATLAB 中的 EEGLAB 工具箱对脑电图信号进行离线预处理和分析。从差异波中提取与情绪处理相关的 ERP 分量特征，并进行统计分析：结果：在对中性和负面情绪线索做出反应时，抑郁症青少年的 P300 波幅明显大于健康对照组。在舍曲林治疗后，抑郁症青少年的抑郁评分和 P300 波幅都明显下降。此外，在治疗前后，抑郁评分的变化与对负面情绪线索反应的P300振幅变化之间存在很强的正相关性：结论：舍曲林可选择性地调节患有抑郁症的青少年对负面情绪刺激的神经反应性变化，而且这种变化与抑郁症状的改善显著相关：意义：P300振幅对负面情绪刺激的变化与抑郁症青少年对舍曲林治疗的反应性明显相关。

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Changes in P300 amplitude to negative emotional stimuli correlate with treatment responsiveness to sertraline in adolescents with depression

Objective

Adolescents with depression is characterized by high rates of recurrence and functional impairment, with a significant association with suicide risk. Antidepressants are commonly prescribed to treat depression, yet few reproducible neurobiological markers for depression and antidepressant treatment response have been identified. Therefore, discovering a stable and reliable neurobiological marker holds significant value for both the clinical diagnosis and treatment of depression in adolescents.

Methods

One hundred and seven patients with major depressive disorder (MDD group, 30 males, 77 females, mean age: 14.80 years), and 25 healthy subjects (HC group, 13 males, 12 females, mean age: 15.72 years) were recruited to perform a two-choice oddball task related to negative emotional cues. All participants completed a self-administered questionnaire to gather demographic information. A trained psychiatrist administered the Hamilton Depression Scale (HAMD-17) to assess depression severity. Of the 107 adolescents with depression, 61 received antidepressant medication for 8 weeks, and 61 of these patients were followed up. Multichannel EEG was recorded continuously from 64 scalp electrodes using the Curry 8 system. EEG signal preprocessing and analysis was performed offline using the EEGLAB toolbox in MATLAB. The ERP component characteristics associated with emotional processing were extracted from the difference waves and statistically analyzed.

Results

Adolescents with depression exhibited significantly larger P300 amplitudes than healthy controls in response to both neutral and negative emotional cues. Following sertraline treatment, both depression scores and P300 amplitudes decreased significantly in adolescents with depression. Moreover, a strong positive correlation was observed between changes in depression scores and changes in P300 amplitude in response to negative emotional cues before and after treatment.

Conclusions

Changes in neural reactivity to negative emotional stimuli among adolescents with depression can be selectively modulated by sertraline and are significantly associated with improvements in depressive symptoms.

Significance

Changes in P300 amplitude to negative emotional stimuli significantly correlate with treatment responsiveness to sertraline in adolescents with depression.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.