淀粉样蛋白-β 正电子发射断层扫描与磁共振成像在阿尔茨海默病中的诊断性能比较：头对头 Meta 分析。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-10-22 DOI:10.1002/brb3.70111

Fang Li, Jiang Cheng, Kaihui Jin, Li Zhao, Junyong Li, Jia Wu, Xiaolu Ren

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引用次数: 0

摘要

目的这项荟萃分析旨在评估淀粉样蛋白-β正电子发射断层扫描（Aβ PET）和磁共振成像（MRI）在诊断阿尔茨海默病（AD）方面的诊断性能比较：在 PubMed 和 Embase 数据库中进行了广泛检索，以确定截至 2023 年 12 月的可用出版物。如果头对头比较研究评估了 Aβ PET 和 MRI 在诊断阿尔茨海默病方面的诊断性能，则将其纳入研究范围。采用 DerSimonian 和 Laird 方法评估敏感性和特异性，然后通过 Freeman-Tukey 双反正弦变换进行转换：荟萃分析共纳入了六篇文章，涉及 560 名患者。在区分注意力缺失症和轻度认知障碍（MCI）时，两种方法的灵敏度（Aβ PET：0.71，MRI：0.62）和特异性（Aβ PET：0.68，MRI：0.69）相当，没有观察到显著的统计学差异（p = 0.34 和 0.99）。在从正常认知控制（NC）中识别AD时，Aβ PET和MRI显示出相似的结果，灵敏度（Aβ PET：0.93，MRI：0.85）和特异性（Aβ PET：0.95，MRI：0.82）相当，无显著差异（p = 0.38和0.19）。同样，在从 NC 中检测 MCI 时，Aβ PET 和 MRI 都表现出相似的敏感性（Aβ PET：0.69，MRI：0.64）和特异性（Aβ PET：0.75，MRI：0.76），无显著差异（p = 0.40 和 0.94）。然而，在区分AD与MCI（P = 0.03）和AD与NC（P = 0.04）时，18F-FMM似乎比MRI具有更高的特异性：我们的荟萃分析表明，在诊断阿尔茨海默病方面，Aβ PET 与 MRI 具有相似的敏感性和特异性。然而，有限的研究数量可能会影响当前研究的证据；需要进一步的大样本前瞻性研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Comparative Diagnostic Performance of Amyloid-β Positron Emission Tomography and Magnetic Resonance Imaging in Alzheimer's Disease: A Head-to-Head Meta-Analysis

查看原文本刊更多论文

Comparative Diagnostic Performance of Amyloid-β Positron Emission Tomography and Magnetic Resonance Imaging in Alzheimer's Disease: A Head-to-Head Meta-Analysis

Objective

This meta-analysis aimed to evaluate the comparative diagnostic performance of amyloid-β positron emission tomography (Aβ PET) and magnetic resonance imaging (MRI) in diagnosing Alzheimer's disease (AD).

Methods

An extensive search was conducted in the PubMed and Embase databases to identify available publications up to December 2023. Head-to-head comparative studies were included if they evaluated the diagnostic performance of Aβ PET and MRI in diagnosing Alzheimer's disease. Sensitivity and specificity were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman–Tukey double inverse sine transformation.

Results

Six articles involving 560 patients were included in the meta-analysis. When distinguishing AD from mild cognitive impairment (MCI), both methods showed comparable sensitivity (Aβ PET: 0.71, MRI: 0.62) and specificity (Aβ PET: 0.68, MRI: 0.69), with no statistically significant differences observed (p = 0.34 and 0.99). When identifying AD from normal cognitive control (NC), both Aβ PET and MRI showed similar results, with comparable sensitivity (Aβ PET: 0.93, MRI: 0.85) and specificity (Aβ PET: 0.95, MRI: 0.82), without significant differences (p = 0.38 and 0.19). Similarly, in detecting MCI from NC, both Aβ PET and MRI demonstrated similar sensitivity (Aβ PET: 0.69, MRI: 0.64) and specificity (Aβ PET: 0.75, MRI: 0.76) without significant differences (p = 0.40 and 0.94). However, 18F-FMM seems to have a higher specificity compared to MRI when distinguishing AD from MCI (P = 0.03) and AD from NC (p = 0.04).

Conclusions

Our meta-analysis indicates that Aβ PET demonstrates similar sensitivity and specificity to MRI in diagnosing Alzheimer's disease. However, the limited number of studies may impact the evidence of the current study; further larger sample prospective research is required to confirm these findings.

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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