寨卡病毒诱导神经发病的机制。

IF 2.1 4区生物学 Q3 MICROBIOLOGY

Brazilian Journal of Microbiology Pub Date : 2024-10-18 DOI:10.1007/s42770-024-01543-3

Nahla Ahmed Hassaan, Li Xing

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引用次数: 0

摘要

寨卡病毒（ZIKV）是一种黄病毒，是最严重的新发病原体之一。在美洲爆发的寨卡病毒疫情越来越多，导致了严重的临床症状，包括成人的格林-巴利综合征和新生儿的先天性畸形。ZIKV 以多种方式影响脑细胞，主要是细胞凋亡和细胞周期延迟。宿主免疫反应和炎症过程的调节也被证明与 ZIKV 引起的神经系统疾病有关。这篇综述总结并讨论了ZIKV研究的最新进展，为ZIKV诱导神经发病机制的多重机制提供了新的启示。

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The mechanisms of Zika virus-induced neuropathogenesis.

Zika virus (ZIKV), a flavivirus, is one of the most serious re-emerging pathogens. Growing outbreaks in the Americas have linked ZIKV to significant clinical symptoms including Guillain-Barré syndrome in adults and congenital anomalies in newborns. ZIKV affects brain cells in a variety of ways, mostly apoptosis and cell cycle delays. Modulation of the host's immune reaction and the inflammatory process has also been shown to be involved in ZIKV-induced neurological disorders. This review summarized and discussed the latest advances in ZIKV research to shed fresh light on the multiple mechanisms incolved in ZIKV-induced neuropathogenesis.

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来源期刊

Brazilian Journal of Microbiology 生物-微生物学

CiteScore

4.10

自引率

4.50%

发文量

216

审稿时长

1.0 months

期刊介绍： The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.