用 5 氟尿嘧啶注射液和膜切除术治疗角膜上皮增生，成功保留了角膜内皮。

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2024-10-15 DOI:10.1186/s12886-024-03719-9

Ka Wai Kam, Andre Ma, Joanna Ng, Paul Choi, Wilson Wai Kuen Yip, Alvin L Young

{"title":"用 5 氟尿嘧啶注射液和膜切除术治疗角膜上皮增生，成功保留了角膜内皮。","authors":"Ka Wai Kam, Andre Ma, Joanna Ng, Paul Choi, Wilson Wai Kuen Yip, Alvin L Young","doi":"10.1186/s12886-024-03719-9","DOIUrl":null,"url":null,"abstract":"A 74-year-old Chinese man underwent extracapsular cataract extraction in his right eye and developed a translucent iris membrane 4 months later. He was treated with two intracameral 5-FU injections and membranectomy at 2 weeks apart. At one year following the second membranectomy, the patient maintained a clear cornea without residual or recurrent membrane, an endothelial cell density of 1072 cell/mm2, a visual acuity of 20/50 and a normal intraocular pressure. Our technique of using dispersive and cohesive viscoelastics in protecting the corneal endothelium from intracameral 5-FU, helped preserve corneal endothelial cells and maintain corneal clarity at one year after surgery.","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"24 1","pages":"450"},"PeriodicalIF":1.7000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476867/pdf/","citationCount":"0","resultStr":"{\"title\":\"Successful corneal endothelium preservation in the management of epithelial downgrowth with 5-fluorouracil injections and membranectomy.\",\"authors\":\"Ka Wai Kam, Andre Ma, Joanna Ng, Paul Choi, Wilson Wai Kuen Yip, Alvin L Young\",\"doi\":\"10.1186/s12886-024-03719-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 74-year-old Chinese man underwent extracapsular cataract extraction in his right eye and developed a translucent iris membrane 4 months later. He was treated with two intracameral 5-FU injections and membranectomy at 2 weeks apart. At one year following the second membranectomy, the patient maintained a clear cornea without residual or recurrent membrane, an endothelial cell density of 1072 cell/mm2, a visual acuity of 20/50 and a normal intraocular pressure. Our technique of using dispersive and cohesive viscoelastics in protecting the corneal endothelium from intracameral 5-FU, helped preserve corneal endothelial cells and maintain corneal clarity at one year after surgery.\",\"PeriodicalId\":9058,\"journal\":{\"name\":\"BMC Ophthalmology\",\"volume\":\"24 1\",\"pages\":\"450\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476867/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12886-024-03719-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12886-024-03719-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

一名 74 岁的中国男性接受了右眼囊外白内障摘除术，4 个月后出现了半透明虹膜。他接受了两次巩膜内注射 5-FU 的治疗，并在间隔两周后进行了膜切除术。第二次膜切除术后一年，患者的角膜保持透明，没有残留或复发的膜，内皮细胞密度为 1072 个细胞/平方毫米，视力为 20/50，眼压正常。我们使用分散粘弹剂和粘合粘弹剂保护角膜内皮不受腔内 5-FU 影响的技术有助于保存角膜内皮细胞，并在术后一年保持角膜清晰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Successful corneal endothelium preservation in the management of epithelial downgrowth with 5-fluorouracil injections and membranectomy.

A 74-year-old Chinese man underwent extracapsular cataract extraction in his right eye and developed a translucent iris membrane 4 months later. He was treated with two intracameral 5-FU injections and membranectomy at 2 weeks apart. At one year following the second membranectomy, the patient maintained a clear cornea without residual or recurrent membrane, an endothelial cell density of 1072 cell/mm², a visual acuity of 20/50 and a normal intraocular pressure. Our technique of using dispersive and cohesive viscoelastics in protecting the corneal endothelium from intracameral 5-FU, helped preserve corneal endothelial cells and maintain corneal clarity at one year after surgery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.