{"title":"孕产妇贫血与新生儿贫血之间的关系:系统回顾与荟萃分析。","authors":"Bokang Zhao, Mengxing Sun, Tianchen Wu, Jiaxin Li, Huifeng Shi, Yuan Wei","doi":"10.1186/s12884-024-06832-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Importance: </strong>Neonatal anemia has a long-term effect on children's growth and development. Anemia during pregnancy is also the most widespread nutritional deficiency among pregnant women in the world; If it leads to anemia in newborns, it will affect a wide range of people and be a public health problem worthy of attention.</p><p><strong>Objective: </strong>To study the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.</p><p><strong>Data sources: </strong>PubMed, Web of science, Scopus, MEDLINE, Embase, ProQuest, Dissertations & Theses Global, The Cochrane Library, China Biology Medicine Database, Chinese CNKI Database, and Chinese Wanfang Database were systematically searched from inception to August 31, 2022.</p><p><strong>Study selection: </strong>The meta-analysis included all original studies which pertain to cohort studies, case-control studies or cross-sectional studies that investigated the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.</p><p><strong>Data extraction and synthesis: </strong>Hemoglobin level of both anemic and non-anemic pregnant mothers and their paired newborns were pooled from the selected studies. The random-effects model was used to assess the risk of getting a lower neonatal hemoglobin level between mothers with and without pregnant anemia. Data analyses were performed from September 5, 2022, to March 10, 2023.</p><p><strong>Main outcomes and measures: </strong>Maternal anemia during pregnancy is a risk factor of lower neonatal hemoglobin levels.</p><p><strong>Results: </strong>The initial search yielded 4267 records of which 116 articles underwent full-text evaluation, which identified 18 articles and a total of 1873 patients that were included. The findings of the meta-analysis showed a significant difference between the two groups(MD=-1.38; 95%CI:[-1.96,-0.80]. p<0.01), while the co-effect showed that the neonatal hemoglobin value of anemic mothers was 1.38g/dL lower than that of non-anemic mothers(-1.96,-0.80), suggesting a correlation between maternal anemia lower neonatal hemoglobin levels.</p><p><strong>Conclusions and relevance: </strong>This systematic review and meta-analysis demonstrated that maternal anemia during pregnancy were associated with a lower level of newborn hemoglobin levels. This may enable a better understanding of neonatal anemia and provide guidance towards future development of nutritional supplementation during pregnancy and the prediction of postpartum outcomes.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42022352759.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"24 1","pages":"677"},"PeriodicalIF":2.8000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488222/pdf/","citationCount":"0","resultStr":"{\"title\":\"The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.\",\"authors\":\"Bokang Zhao, Mengxing Sun, Tianchen Wu, Jiaxin Li, Huifeng Shi, Yuan Wei\",\"doi\":\"10.1186/s12884-024-06832-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Importance: </strong>Neonatal anemia has a long-term effect on children's growth and development. Anemia during pregnancy is also the most widespread nutritional deficiency among pregnant women in the world; If it leads to anemia in newborns, it will affect a wide range of people and be a public health problem worthy of attention.</p><p><strong>Objective: </strong>To study the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.</p><p><strong>Data sources: </strong>PubMed, Web of science, Scopus, MEDLINE, Embase, ProQuest, Dissertations & Theses Global, The Cochrane Library, China Biology Medicine Database, Chinese CNKI Database, and Chinese Wanfang Database were systematically searched from inception to August 31, 2022.</p><p><strong>Study selection: </strong>The meta-analysis included all original studies which pertain to cohort studies, case-control studies or cross-sectional studies that investigated the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.</p><p><strong>Data extraction and synthesis: </strong>Hemoglobin level of both anemic and non-anemic pregnant mothers and their paired newborns were pooled from the selected studies. The random-effects model was used to assess the risk of getting a lower neonatal hemoglobin level between mothers with and without pregnant anemia. Data analyses were performed from September 5, 2022, to March 10, 2023.</p><p><strong>Main outcomes and measures: </strong>Maternal anemia during pregnancy is a risk factor of lower neonatal hemoglobin levels.</p><p><strong>Results: </strong>The initial search yielded 4267 records of which 116 articles underwent full-text evaluation, which identified 18 articles and a total of 1873 patients that were included. The findings of the meta-analysis showed a significant difference between the two groups(MD=-1.38; 95%CI:[-1.96,-0.80]. p<0.01), while the co-effect showed that the neonatal hemoglobin value of anemic mothers was 1.38g/dL lower than that of non-anemic mothers(-1.96,-0.80), suggesting a correlation between maternal anemia lower neonatal hemoglobin levels.</p><p><strong>Conclusions and relevance: </strong>This systematic review and meta-analysis demonstrated that maternal anemia during pregnancy were associated with a lower level of newborn hemoglobin levels. 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引用次数: 0
摘要
重要性:新生儿贫血对儿童的生长发育具有长期影响。妊娠期贫血也是世界上孕妇最普遍的营养缺乏症,如果导致新生儿贫血,将影响广泛,是值得关注的公共卫生问题:研究孕妇孕期贫血与新生儿血红蛋白水平之间的关系:数据来源:系统检索了PubMed、Web of science、Scopus、MEDLINE、Embase、ProQuest、Dissertations & Theses Global、The Cochrane Library、中国生物医学数据库、中国CNKI数据库和中国万方数据库,检索时间从开始至2022年8月31日:荟萃分析包括所有研究妊娠期母亲贫血与新生儿血红蛋白水平关系的队列研究、病例对照研究或横断面研究。采用随机效应模型来评估贫血孕妇和非贫血孕妇新生儿血红蛋白水平降低的风险。数据分析时间为2022年9月5日至2023年3月10日:母亲孕期贫血是导致新生儿血红蛋白水平降低的风险因素:初步检索共获得4267条记录,对其中116篇文章进行了全文评估,确定了18篇文章,共纳入1873名患者。荟萃分析结果显示,两组患者之间存在显著差异(MD=-1.38;95%CI:[-1.96,-0.80]):该系统综述和荟萃分析表明,孕期贫血与新生儿血红蛋白水平较低有关。这有助于更好地了解新生儿贫血,并为未来孕期营养补充的发展和产后结果的预测提供指导:试验注册:PROSPERO Identifier:CRD42022352759。
The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis.
Importance: Neonatal anemia has a long-term effect on children's growth and development. Anemia during pregnancy is also the most widespread nutritional deficiency among pregnant women in the world; If it leads to anemia in newborns, it will affect a wide range of people and be a public health problem worthy of attention.
Objective: To study the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.
Data sources: PubMed, Web of science, Scopus, MEDLINE, Embase, ProQuest, Dissertations & Theses Global, The Cochrane Library, China Biology Medicine Database, Chinese CNKI Database, and Chinese Wanfang Database were systematically searched from inception to August 31, 2022.
Study selection: The meta-analysis included all original studies which pertain to cohort studies, case-control studies or cross-sectional studies that investigated the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.
Data extraction and synthesis: Hemoglobin level of both anemic and non-anemic pregnant mothers and their paired newborns were pooled from the selected studies. The random-effects model was used to assess the risk of getting a lower neonatal hemoglobin level between mothers with and without pregnant anemia. Data analyses were performed from September 5, 2022, to March 10, 2023.
Main outcomes and measures: Maternal anemia during pregnancy is a risk factor of lower neonatal hemoglobin levels.
Results: The initial search yielded 4267 records of which 116 articles underwent full-text evaluation, which identified 18 articles and a total of 1873 patients that were included. The findings of the meta-analysis showed a significant difference between the two groups(MD=-1.38; 95%CI:[-1.96,-0.80]. p<0.01), while the co-effect showed that the neonatal hemoglobin value of anemic mothers was 1.38g/dL lower than that of non-anemic mothers(-1.96,-0.80), suggesting a correlation between maternal anemia lower neonatal hemoglobin levels.
Conclusions and relevance: This systematic review and meta-analysis demonstrated that maternal anemia during pregnancy were associated with a lower level of newborn hemoglobin levels. This may enable a better understanding of neonatal anemia and provide guidance towards future development of nutritional supplementation during pregnancy and the prediction of postpartum outcomes.
期刊介绍:
BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.