Ahmet Uyar, Barış Özdere, Turan Yaman, Ahmet Ufuk Kömüroğlu
{"title":"甘草提取物对肥胖大鼠肝脏的影响","authors":"Ahmet Uyar, Barış Özdere, Turan Yaman, Ahmet Ufuk Kömüroğlu","doi":"10.1080/10520295.2024.2401159","DOIUrl":null,"url":null,"abstract":"<p><p>We have investigated anti-obesity effects of the extract of licorice (<i>Glycyrrhiza glabra</i>) root in rats with diet-induced obesity and hyperlipidemia by using histopathological and biochemical methods. Thirty-two Wistar albino rats were divided to four groups of eight: normal control (C), high fat diet (HFD), high fat Diet + <i>Glycyrrhiza glabra</i> (HFD+M), and normal diet with <i>Glycyrrhiza glabra</i> (M). The high fat diet contained 300 g/kg fat (4000 kcal/kg); the daily dosage of <i>Glycyrrhiza glabra</i> extract was 1g/kg body weight by orogastric gavage. Supplementation of <i>Glycyrrhiza glabra</i> extract dramatically reduced increases in body weight caused by the induction of obesity. A hepatoprotective effect of <i>Glycyrrhiza glabra</i> extract was supported by the almost normal histology in the livers of the HFD+M rats, in contrast to the degenerative changes in the HFD rats, which included macrovesicular and microvesicular fat deposits, hydropic degeneration, dilatation of sinusoids and coagulation necrosis of some hepatocytes. Serum levels of alanine transaminase (ALT), aspartic transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol (HDL and LDL) and triglycerides, were ameliorated by <i>Glycyrrhiza glabra</i> extract treatment. We conclude that <i>Glycyrrhiza glabra</i> extract given together with HFD could prevent obesity and reduce liver damage in rats.</p>","PeriodicalId":8970,"journal":{"name":"Biotechnic & Histochemistry","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of licorice root (<i>Glycyrrhiza glabra)</i> extract on the livers of obese rats.\",\"authors\":\"Ahmet Uyar, Barış Özdere, Turan Yaman, Ahmet Ufuk Kömüroğlu\",\"doi\":\"10.1080/10520295.2024.2401159\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We have investigated anti-obesity effects of the extract of licorice (<i>Glycyrrhiza glabra</i>) root in rats with diet-induced obesity and hyperlipidemia by using histopathological and biochemical methods. Thirty-two Wistar albino rats were divided to four groups of eight: normal control (C), high fat diet (HFD), high fat Diet + <i>Glycyrrhiza glabra</i> (HFD+M), and normal diet with <i>Glycyrrhiza glabra</i> (M). The high fat diet contained 300 g/kg fat (4000 kcal/kg); the daily dosage of <i>Glycyrrhiza glabra</i> extract was 1g/kg body weight by orogastric gavage. Supplementation of <i>Glycyrrhiza glabra</i> extract dramatically reduced increases in body weight caused by the induction of obesity. A hepatoprotective effect of <i>Glycyrrhiza glabra</i> extract was supported by the almost normal histology in the livers of the HFD+M rats, in contrast to the degenerative changes in the HFD rats, which included macrovesicular and microvesicular fat deposits, hydropic degeneration, dilatation of sinusoids and coagulation necrosis of some hepatocytes. Serum levels of alanine transaminase (ALT), aspartic transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol (HDL and LDL) and triglycerides, were ameliorated by <i>Glycyrrhiza glabra</i> extract treatment. We conclude that <i>Glycyrrhiza glabra</i> extract given together with HFD could prevent obesity and reduce liver damage in rats.</p>\",\"PeriodicalId\":8970,\"journal\":{\"name\":\"Biotechnic & Histochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biotechnic & Histochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1080/10520295.2024.2401159\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnic & Histochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10520295.2024.2401159","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Effects of licorice root (Glycyrrhiza glabra) extract on the livers of obese rats.
We have investigated anti-obesity effects of the extract of licorice (Glycyrrhiza glabra) root in rats with diet-induced obesity and hyperlipidemia by using histopathological and biochemical methods. Thirty-two Wistar albino rats were divided to four groups of eight: normal control (C), high fat diet (HFD), high fat Diet + Glycyrrhiza glabra (HFD+M), and normal diet with Glycyrrhiza glabra (M). The high fat diet contained 300 g/kg fat (4000 kcal/kg); the daily dosage of Glycyrrhiza glabra extract was 1g/kg body weight by orogastric gavage. Supplementation of Glycyrrhiza glabra extract dramatically reduced increases in body weight caused by the induction of obesity. A hepatoprotective effect of Glycyrrhiza glabra extract was supported by the almost normal histology in the livers of the HFD+M rats, in contrast to the degenerative changes in the HFD rats, which included macrovesicular and microvesicular fat deposits, hydropic degeneration, dilatation of sinusoids and coagulation necrosis of some hepatocytes. Serum levels of alanine transaminase (ALT), aspartic transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol (HDL and LDL) and triglycerides, were ameliorated by Glycyrrhiza glabra extract treatment. We conclude that Glycyrrhiza glabra extract given together with HFD could prevent obesity and reduce liver damage in rats.
期刊介绍:
Biotechnic & Histochemistry (formerly Stain technology) is the
official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926.
Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well.
Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.