光动力打开血脑屏障会影响健康雄性小鼠的脑膜淋巴管和大脑引流。

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI:10.1364/BOE.527892

Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya

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引用次数: 0

摘要

在这里，我们介绍了 5-aminolevulinic acid（5-ALA）光动力疗法（PDT）对血管的新影响。5-ALA 光动力疗法会导致脑膜和脑血管渗漏。光激发的 5-ALA 从渗漏的血管外渗到脑膜，对脑膜淋巴管（MLV）造成光损伤，导致 MLV 网络和大脑引流急剧减少。光透射疗法引起的脑引流淋巴调节功能障碍会导致脑组织内液体过度积聚，这是用 5-ALA 进行光透射疗法治疗脑部疾病时必须考虑的一个重要问题，也是光透射疗法可能产生的副作用。

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Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.

Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.