用于多重检测肝功能血液标记物的微流控护理点检测设备。

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2024-09-09 eCollection Date: 2024-10-01 DOI:10.1364/BOE.533855

Yingchun Li, Haobo Cheng

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引用次数: 0

摘要

在这项工作中，我们开发了一种新型的微流体纸基分析装置，用于从人体指尖和全血样本中定量检测肝功能的血液指标。该装置可同时对丙氨酸氨基转移酶、天门冬氨酸氨基转移酶和白蛋白进行定量检测，从而快速获取肝损伤筛查信息，为临床决策提供支持。我们使用指尖样本对设备的检测准确性和储存稳定性进行了评估。即使在 35 °C 和 90%RH 的条件下，我们设备的检测结果与 Mindray BS350 的结果也有很好的相关性。因此，它为临床评估肝损伤提供了一个有效的平台，尤其是在资源有限的地区。

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Microfluidic point-of-care testing device for multiplexed detection of liver function blood markers.

In this work, we developed a novel microfluidic paper-based analytical device to quantify the blood markers of liver function from human fingertips and whole blood samples. The device can quickly acquire information for screening liver injury and supporting clinical decision-making by simultaneously performing quantitative tests for alanine aminotransferase, aspartate aminotransferase, and albumin. We evaluated the detection accuracy and the storage stability of the device using fingertip samples. The yielded results of our device correlated well with those from Mindray BS350s, even under the conditions of 35 °C and 90%RH. Thus, it offers an effective platform for clinical assessment of liver injury particularly in resource-limited areas.

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.