Delphinidin或α-amyrin可减轻高脂饮食大鼠的肝脏脂肪变性和代谢紊乱。

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2024-10-21 DOI:10.1002/biof.2133
Bassam Mohamed Ali, Eman M Elbaz, Asmaa K Al-Mokaddem, Soad Z El-Emam, Magdy M Awny
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)是一种伴有代谢紊乱的肝脏病变。本研究评估了花青素 delphinidin 或五环三萜类化合物 α-amyrin 对大鼠非酒精性脂肪肝的治疗作用及其潜在机制。非酒精性脂肪肝是通过给大鼠喂食高脂饮食(HFD)10周,单独或联合使用Delphinidin(40毫克/千克,口服)或α-amyrin(20毫克/千克,口服)来建立的。Delphinidin或α-amyrin可改善高氟日粮引起的代谢和组织病理学紊乱。这些化合物明显减轻了非酒精性脂肪肝引起的肝脏脂肪变性,体重、胰岛素抵抗、肝脏和脂肪组织指数的大幅下降就是证明。在使动脉粥样硬化指数正常化的同时,这两种药物还改善了高密度脂蛋白胆固醇介导的血清脂质、肝酶、瘦素和胃泌素水平异常。此外,它们的干预还激活了 NFE2 类似于 bZIP 转录因子 2 和血红素加氧酶 1 的通路,并减弱了 HFD 触发的丝裂原活化蛋白激酶 1 信号的激活。这些疗法抑制了肝细胞凋亡,并调节了脂肪生成酶的基因表达。此外,组织学分析也证实,治疗大鼠的脂质积累受到抑制,肝脏结构得到改善。我们的研究结果突出表明,通过胰岛素增敏、抗炎、抗氧化和抗凋亡作用,德尔菲尼丁或α-amyrin对非酒精性脂肪肝和相关代谢疾病具有保护肝脏的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Delphinidin or α-amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high-fat diet.

Non-alcoholic fatty liver disease (NAFLD) is a liver pathology concomitant with metabolic disarrangement. This study assessed the therapeutic impacts of delphinidin, an anthocyanin, or α-amyrin, a pentacyclic triterpenoid, on NAFLD in rats and the underlying mechanisms involved. NAFLD was established by feeding a high-fat diet (HFD) for 10 weeks, either alone or in combination with delphinidin (40 mg/kg, oral) or α-amyrin (20 mg/kg, oral). Delphinidin or α-amyrin ameliorated the metabolic and histopathological perturbations induced by HFD. These compounds markedly attenuated NAFLD-induced hepatic steatosis, as evidenced by a substantial decrease in body weight, insulin resistance, and liver and adipose tissue indices. Alongside normalization of the atherogenic index, both improved HFD-mediated abnormalities in serum lipids, liver enzymes, leptin, and ghrelin levels. Moreover, their intervention activated the NFE2 like bZIP transcription factor 2 and heme oxygenase 1 pathways and abrogated HFD-triggered activation of mitogen-activated protein kinase 1 signaling. These remedies inhibited hepatic apoptosis and modulated the gene expression of lipogenic enzymes. Furthermore, histological analysis corroborated the suppression of lipid accumulation and amelioration of hepatic architecture in the treated rats. Our findings highlight the hepatoprotective value of delphinidin or α-amyrin against NAFLD and related metabolic diseases through their insulin-sensitizing, anti-inflammatory, antioxidant, and antiapoptotic effects.

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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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