无肾脏疾病的阿尔茨海默病患者队列中肌酐水平对淀粉样蛋白-β和tau血浆浓度的影响。

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Francesco Motolese , Davide Norata , Gianmarco Iaccarino , Elisabetta Sapio , Fioravante Capone
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引用次数: 0

摘要

背景:阿尔茨海默病(AD)的病理特征是β-淀粉样蛋白和tau蛋白的沉积。血液生物标志物(BBM)可用于检测体内这些异常蛋白。由于肾脏是重要的排泄器官,肾功能下降可能会影响 BBM 的清除。在这项研究中,我们旨在评估一组经生物学诊断为AD但无慢性肾病(CKD)的患者的肾功能、BBM水平和认知障碍之间的关系:这是一项针对AD患者的回顾性队列研究。方法:这是一项针对AD患者的回顾性队列研究。研究人员收集了诊断时(T0)的病史数据,以及T0和6个月后(T1)的迷你精神状态检查(MMSE)评分。收集脑脊液和血液样本,并使用市售试剂盒测定Aβ42、Aβ40、t-Tau和p-Tau181的浓度。肾功能通过 2021-CKD-EPI 公式进行估算。为了评估肌酐对相关参数的影响,我们将患者分为两组--肌酐水平组 结果显示,肌酐水平组患者的 MMSE 评分中位数较低,而肌酐水平组患者的 MMSE 评分中位数较高:中位 MMSE 评分在两个时间点之间明显下降。当我们评估亚组之间相关参数的差异时,我们发现只有 Aβ42 血浆水平在高组与低组之间存在明显差异:结论:我们发现只有 Aβ42 血浆水平受肾功能影响,而其他 AD 生物标志物不受肌酐水平或 eGFR 的影响。我们的研究结果与 Aβ 同工酶肾清除假说一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of creatinine level on amyloid-β and tau plasma concentrations in a cohort of Alzheimer’s disease patients without kidney disease

Background

Alzheimer’s disease (AD) is pathologically characterized by the deposition of beta-amyloid and tau-protein. Blood biomarkers (BBM) might be employed for detecting these abnormal proteins in vivo. As the kidney is an important excretory organ, a decreased renal function might affect the clearance of BBM. In this study we aimed to assess the relationship between kidney function, the levels of BBM and cognitive impairment in a cohort of patients with a biological AD diagnosis without chronic kidney disease (CKD).

Methods

This is a retrospective cohort study on AD patients. Data regarding medical history at diagnosis (T0) were retrieved, together with the Mini-Mental State Examination (MMSE) score at T0 and after 6 months (T1). Cerebrospinal fluid and blood samples were collected and concentrations of Aβ42, Aβ40, t-Tau, and p-Tau181 were determined using commercially available kits. Kidney function was estimated through the 2021-CKD-EPI equation. To assess the effects of creatinine on our parameters of interest, we grouped patients into two groups –creatinine level <0.8 mg/dl (LOW) or ≥0.8 mg/dl (HIGH).

Results

The median MMSE score decreased significantly between the two timepoints. When we assessed for differences in the parameters of interest between subgroups, we found that only Aβ42 plasma level was significantly different in the HIGH vs LOW group.

Conclusion

We found out that only Aβ42 plasma levels are influenced by kidney function, while the other AD biomarkers are not affected by creatinine levels or eGFR. Our findings are consistent with the hypothesis of renal clearance of Aβ isoforms.
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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