喙状前扣带回皮层的血清素能、GABA 能和谷氨酸能系统参与成年雄性 Wistar 大鼠的性状和状态焦虑。

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Thiago Henrique Almeida-Souza , Rodolfo Santos Silva , Heitor Santos Franco , Leandra Martins Santos , João Eduardo Conceição Melo , Ana Mara de Oliveira e Silva , Edênia Cunha de Menezes , José Ronaldo dos Santos , Flavia Teixeira-Silva , Tiago Costa Goes , Murilo Marchioro
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引用次数: 0

摘要

尽管在了解焦虑所涉及的神经回路方面取得了重大进展,但特质焦虑的神经生物学仍不清楚。喙状前扣带回皮层(rACC)和各种通路都与它的调节有关,因此它是特质焦虑的关键。本研究旨在探讨这些神经递质系统在性焦虑中的作用。众所周知,特质焦虑会调节状态焦虑,因此我们进一步研究了这种关系。具体来说,在实验一中,我们使用了高特质焦虑的动物;在实验二中,我们使用了低特质焦虑的动物;在实验三中,我们使用了中等特质焦虑的动物。在每次行为评估之前,我们都会在 rACC 中使用增加或减少血清素能(氟西汀或 WAY-100635)、GABA 能(Muscimol 或 Bicuculline)和谷氨酸能(NMDA 或 Ketamine)神经递质的药物,并同时使用相应的对照药物。此外,在实验四中,对之前实验中的所有动物进行了高架迷宫(EPM)和孔板(HB)测试,并在不考虑其特质焦虑水平的情况下进行了评估。本研究的结果表明,在实验一中,调节 rACC 中的血清素能、GABA 能和谷氨酸能系统可降低高度焦虑大鼠的特质焦虑,而让动物接受 HB 测试则可增加其状态焦虑。在实验 II 中,对所有系统的调节都会增加低特质焦虑大鼠的特质焦虑,而在 HB 中,服用 NMDA 会增加状态焦虑水平。在实验三中,只有使用 NMDA 对谷氨酸能系统进行调节,才能同时提高特质焦虑和状态焦虑水平。然而,所评估的神经递质系统均未改变 EPM 中的状态焦虑模型。总之,本研究的结果为了解 rACC 中的神经递质系统在调节特质焦虑和状态焦虑中的作用提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Involvement of the serotonergic, GABAergic and glutamatergic systems of the rostral anterior cingulate cortex in the trait and state anxiety of adult male Wistar rats.
Despite significant advancements to understand of the neural circuitry involved in anxiety, the neurobiology of trait anxiety remains unclear. The rostral anterior cingulate cortex (rACC) and various pathways have been implicated in its regulation, making it a key to trait anxiety. The present study aimed to investigate the role of these neurotransmitter systems in the rACC in trait anxiety. Since trait anxiety is known to modulate state anxiety, we further investigated this relationship. Specifically, in Experiment I, we used animals with high trait anxiety; in Experiment II, we used animals with low trait anxiety; and in Experiment III, we used animals with medium trait anxiety. Before each behavioral assessment, drugs that either increased or decreased serotonergic (Fluoxetine or WAY-100635), GABAergic (Muscimol or Bicuculline), and glutamatergic (NMDA or Ketamine) neurotransmission in the rACC were administered, along with their respective controls. Additionally, in Experiment IV, all animals from the previous experiments were subjected to the Elevated Plus Maze (EPM) and Hole board (HB) test and evaluated without taking into account their trait anxiety levels. The results of the present study showed that, in Exp I, the modulation of the serotonergic, GABAergic and glutamatergic systems in the rACC decreased trait anxiety in highly anxious rats, while by submitting the animals to HB, the administration of fluoxetine increased state anxiety. In Exp II, the modulation of all systems increased trait anxiety in rats with low trait anxiety, whereas, in HB, state anxiety levels were increased with the administration of NMDA. In Exp III, only the modulation of the glutamatergic system, with NMDA, increased both trait and state anxiety levels. However, none of the evaluated neurotransmitter systems altered the state anxiety modeled in the EPM. Overall, the results of the present study provide new insights into the role of the neurotransmitter systems in the rACC in the regulation of trait anxiety and state anxiety.
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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