迷走神经刺激治疗痴呆症:临床和临床前研究范围综述。

IF 3.1 Q2 NEUROSCIENCES
AIMS Neuroscience Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024024
Ronald Kamoga, Godfrey Zari Rukundo, Samuel Kalungi, Wilson Adriko, Gladys Nakidde, Celestino Obua, Johnes Obongoloch, Amadi Ogonda Ihunwo
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引用次数: 0

摘要

背景:痴呆症是一种多因素导致的流行性、进行性神经退行性疾病。由于缺乏治疗痴呆症的有效药物,使用迷走神经刺激(VNS)作为治疗痴呆症的潜在非药物疗法的临床和研究兴趣日益浓厚。然而,人们对迷走神经刺激对痴呆症的影响的研究范围和性质还不甚了解。本研究旨在考察与 VNS 用于痴呆症相关的研究活动的范围和性质,并传播研究结果,以了解其在痴呆症护理中的潜在作用:我们对1980年至2023年11月30日期间在PubMed、HINARI、Google Scholar和Cochrane数据库中进行的文献检索进行了范围审查,包括已确定研究的参考文献目录。使用了以下检索词:脑刺激、痴呆、阿尔茨海默病、迷走神经刺激、记忆力减退、Deme*、cognit*、VNS 和颅神经刺激。纳入的研究符合以下条件:纵向和横断面研究设计中涉及人类和动物的主要研究文章,发表于 1980 年 1 月 1 日至 2023 年 11 月 30 日期间的英语文章;研究 VNS 治疗痴呆症或认知障碍的文章;非病例研究、会议记录/摘要、评论或普通综述论文:我们确定了 8062 篇文章,经过资格筛选(按顺序阅读标题、摘要和全文,并删除重复内容),10 项研究被纳入综述。本次文献综述所纳入的所有研究都是过去 30 年间在高收入地区(即欧洲、美国、英国和中国)进行的,其中大部分(7/10)是在人体中进行的。据报道,在痴呆症病例中使用 VNS 的主要结果是认知功能增强、参与学习和记忆的各大脑区域的功能连接性增强、小胶质细胞结构从神经破坏性构型转变为神经保护性构型、脑脊液 tau 蛋白减少,以及可用于诊断神经退行性疾病的脑组织诱发电位显著增强。研究结果凸显了 VNS 作为一种非药物疗法治疗阿尔茨海默病等痴呆相关疾病认知障碍的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vagus nerve stimulation in dementia: A scoping review of clinical and pre-clinical studies.

Background: Dementia is a prevalent, progressive, neurodegenerative condition with multifactorial causes. Due to the lack of effective pharmaceutical treatments for dementia, there are growing clinical and research interests in using vagus nerve stimulation (VNS) as a potential non-pharmacological therapy for dementia. However, the extent of the research volume and nature into the effects of VNS on dementia is not well understood. This study aimed to examine the extent and nature of research activities in relation to the use of VNS in dementia and disseminate research findings for the potential utility in dementia care.

Methods: We performed a scoping review of literature searches in PubMed, HINARI, Google Scholar, and the Cochrane databases from 1980 to November 30th, 2023, including the reference lists of the identified studies. The following search terms were utilized: brain stimulation, dementia, Alzheimer's disease, vagal stimulation, memory loss, Deme*, cognit*, VNS, and Cranial nerve stimulation. The included studies met the following conditions: primary research articles pertaining to both humans and animals for both longitudinal and cross-sectional study designs and published in English from January 1st, 1980, to November 30th, 2023; investigated VNS in either dementia or cognitive impairment; and were not case studies, conference proceedings/abstracts, commentaries, or ordinary review papers.

Findings and conclusions: We identified 8062 articles, and after screening for eligibility (sequentially by titles, abstracts and full text reading, and duplicate removal), 10 studies were included in the review. All the studies included in this literature review were conducted over the last three decades in high-income geographical regions (i.e., Europe, the United States, the United Kingdom, and China), with the majority of them (7/10) being performed in humans. The main reported outcomes of VNS in the dementia cases were enhanced cognitive functions, an increased functional connectivity of various brain regions involved in learning and memory, microglial structural modifications from neurodestructive to neuroprotective configurations, a reduction of cerebral spinal fluid tau-proteins, and significant evoked brain tissue potentials that could be utilized to diagnose neurodegenerative disorders. The study outcomes highlight the potential for VNS to be used as a non-pharmacological therapy for cognitive impairment in dementia-related diseases such as Alzheimer's disease.

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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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