后天性和先天性肛门畸形患者的楔形板孔计数。

IF 2.5 3区 医学 Q1 OTORHINOLARYNGOLOGY
Jerry Hadi Juratli, Brigit High, Akshita Joshi, Eren Yilmaz, Duzgun Yildirim, Aytug Altundag, Thomas Hummel
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引用次数: 0

摘要

背景:楔形孔是嗅神经纤维从鼻腔进入嗅球的开口。已知嗅神经纤维的中断会影响嗅觉功能,但对先天性嗅觉缺失症患者楔形孔数量的潜在影响却知之甚少:这项试验性研究旨在调查与嗅觉功能正常的对照组相比,获得性和先天性嗅觉缺失症(包括卡尔曼综合征和孤立性先天性嗅觉缺失症)患者的楔孔数量是否减少:分析了20名先天性嗅觉缺失(6人)、后天性嗅觉缺失(6人)或嗅觉功能正常(8人)患者的鼻旁CT图像。由三位观察者从显示嵴胆和乙状缝的切片上对嵴孔进行计数。采用单因素方差分析法对每个受试者最接近的两个数值进行比较分析:结果:先天性而非后天性无虹膜症患者的楔形孔(x̄ ± SE = 10.17 ± 1.23)明显少于正常健康对照组(x̄ ± SE = 19.88 ± 2.01)。先天性无肛症患者和后天性无肛症患者的肛门孔数量无明显差异(x̄ ± SE = 15.83 ± 3.47):在这项试验性研究中,发现先天性无肛症患者的楔形孔数量减少。检查楔状孔有助于为嗅觉缺失患者提供咨询。有必要在更大规模的研究中对更多人群进行进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cribriform Plate Foramina Count in Patients With Acquired and Congenital Anosmia.

Background: Cribriform foramina provide the openings for olfactory nerve fibers to cross from the nasal cavity to the olfactory bulb. Disruption of the olfactory nerve fibers is known to affect olfactory function, but little is known about the potential effects on the number of cribriform foramina in congenital anosmia.

Objective: This pilot study aimed to investigate whether there was a reduction in foramina in patients with acquired and congenital anosmia (including both Kallmann syndrome and isolated congenital anosmia) compared to controls with normal olfactory function.

Methods: Paranasal CT image stacks were analyzed from 20 patients with congenital anosmia (n = 6), acquired anosmia (n = 6), or normal olfactory function (n = 8). Cribriform foramina were counted by three observers from the slice revealing the crista galli and the ethmoidal slits. The two closest values for each subject were analyzed in comparison across the three groups using one-way analysis of variance.

Results: Patients with congenital, but not acquired, anosmia had significantly fewer cribriform foramina (x̄ ± SE = 10.17 ± 1.23) compared to healthy, normosmic controls (x̄ ± SE = 19.88 ± 2.01). There was no significant difference in foramina count between congenital and acquired anosmics (x̄ ± SE = 15.83 ± 3.47).

Conclusion: In this pilot study, a reduced number of cribriform foramina was found in individuals with congenital anosmia. Examination of cribriform foramina could be helpful in counseling patients with olfactory loss. Further investigation in larger studies with additional cohorts is warranted.

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来源期刊
CiteScore
5.60
自引率
11.50%
发文量
82
审稿时长
4-8 weeks
期刊介绍: The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
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