鉴定重要的细胞基因对于验证药物靶点至关重要。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-10-18 DOI:10.1016/j.drudis.2024.104215

Ting Xu , Shuang Wang , Tingting Ma , Yawen Dong , Charles R. Ashby Jr , Ge-Fei Hao

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引用次数: 0

摘要

准确识别生物靶点对于改进治疗方案至关重要。对细胞或生物体生存至关重要的重要基因有望成为治疗疾病的潜在药物靶点。尽管许多研究都试图将重要基因确定为医学和生物信息学中的治疗靶点，但有关其与药物靶点关系的系统性综述却相对罕见。本研究对基本基因的相关性、识别方法、成功案例研究以及面临的挑战进行了全面的分析，以帮助识别作为药物发现潜在靶点的基本基因。这项工作将有助于确定作为治疗靶点的重要基因，从而促进新药开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The identification of essential cellular genes is critical for validating drug targets

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The identification of essential cellular genes is critical for validating drug targets

Accurately identifying biological targets is crucial for advancing treatment options. Essential genes, vital for cell or organism survival, hold promise as potential drug targets in disease treatment. Although many studies have sought to identify essential genes as therapeutic targets in medicine and bioinformatics, systematic reviews on their relationship with drug targets are relatively rare. This work presents a comprehensive analysis to aid in identifying essential genes as potential targets for drug discovery, encompassing their relevance, identification methods, successful case studies, and challenges. This work will facilitate the identification of essential genes as therapeutic targets, thereby boosting new drug development.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.