肽作为抗癌疗法中抗药性的创新策略。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-10-10 DOI:10.1016/j.drudis.2024.104206

Henry O. Lamb , Aurélie H. Benfield , Sónia Troeira Henriques

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引用次数: 0

摘要

耐药性是癌症患者治疗失败的主要原因。因此，需要创新的治疗策略来克服这一严峻挑战并改善患者的预后。在这篇综述中，我们探讨了基于多肽的疗法在抗击癌症耐药性方面的潜力。我们强调了使用多肽可以探索的独特策略和机制，包括多肽选择性靶向肿瘤、促进药物输送到癌细胞以及抑制驱动癌症进展和耐药性的关键细胞内蛋白的能力。肽为克服癌症对化疗、靶向疗法和生物制剂的内在和适应性抗药性提供了一种前景广阔的方法。

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Peptides as innovative strategies to combat drug resistance in cancer therapy

Drug resistance is the leading cause of treatment failure in patients with cancer. Thus, innovative therapeutic strategies are required to overcome this critical challenge and improve patient outcomes. In this review, we examine the potential of peptide-based therapies to combat drug resistance in cancer. We highlight the unique strategies and mechanisms that can be explored by using peptides, including their ability to selectively target tumours, facilitate drug delivery into cancer cells, and inhibit key intracellular proteins that drive cancer progression and resistance. Peptides offer a promising approach to overcoming both intrinsic and adaptative cancer resistance against chemotherapy, targeted therapies, and biologics.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.