晚期宫颈癌的炎症和血栓风险：对南非队列中凝血和细胞因子特征的探索性研究。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-10-20 DOI:10.1016/j.cyto.2024.156782

Louise Fourie , Claudia Christowitz , Carla Eksteen , Haynes van der Merwe , Hennie Botha , Chantelle Venter , Anna-Mart Engelbrecht

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引用次数: 0

摘要

目的：这项探索性研究调查了南非宫颈癌患者的炎症与血栓形成之间可能存在的关系，强调了改进血栓形成风险分析的必要性：方法：采用血栓弹性成像（TEG）技术评估一小群晚期（III 和 IV 期）宫颈癌患者（19 人）和健康对照组（15 人）贫血小板血浆（PPP）中的凝血参数。评估参数包括凝血时间、凝血形成速度和凝血强度。使用 Luminex Multiplex 分析法检测 PPP 中的干扰素-γ（IFN-γ）、白细胞介素-1β（IL-1β）、IL-6、血管内皮生长因子-A（VEGF-A）和肿瘤坏死因子-α（TNF-α）。此外，还对血液学特征进行了评估：结果：宫颈癌患者的凝血时间明显缩短（p = 0.0044），凝血强度增加（p = 0.0003），表明凝血功能增强。IL-1β 明显升高（p = 0.0200），与炎症环境一致。观察到淋巴细胞、中性粒细胞和血小板计数升高（分别为 p = 0.0162、0.0420 和 0.0374），表明可能存在促血栓形成状态：结论：这些研究结果表明，宫颈癌患者的炎症与血栓形成之间存在潜在联系。结论：这些研究结果表明，宫颈癌患者的炎症与血栓形成之间存在潜在联系。然而，由于本研究的样本量较小，且属于探索性研究，因此这些因素之间的直接关系尚未明确确定，仍属于推测。血栓形成风险分析可能对患者的管理仍有价值，但还需要进一步的研究来证实这些初步观察结果。

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Inflammation and thrombotic risk in late-stage cervical cancer: An exploratory study of coagulation and cytokine profiles in a South African cohort

Purpose

This exploratory study investigates the possible relationship between inflammation and thrombosis in cervical cancer patients in South Africa, highlighting the need for improved thrombotic risk profiling.

Methods

Thromboelastography (TEG) was used to assess coagulation parameters in platelet-poor plasma (PPP) from a small cohort of late-stage (III and IV) cervical cancer patients (n = 19) and healthy controls (n = 15). Parameters assessed included clotting time, clot formation speed, and clot strength. A Luminex Multiplex assay was used to measure interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-6, vascular endothelial growth factor-A (VEGF-A), and tumour necrosis factor-α (TNF-α) in PPP. Haematological profiles were also evaluated.

Results

Cervical cancer patients displayed a significantly shortened clotting time (p = 0.0044) and increased clot strength (p = 0.0003), suggesting enhanced coagulation. IL-1β was notably elevated (p = 0.0200), consistent with an inflammatory environment. Higher lymphocyte, neutrophil, and platelet counts (p = 0.0162, 0.0420, and 0.0374, respectively) were observed, indicating a possible prothrombotic state.

Conclusion

These findings suggest a potential link between inflammation and thrombosis in cervical cancer patients. However, due to this study’s small sample size and exploratory nature, direct relationships between these factors have yet to be definitively established and remain speculative. Thrombotic risk profiling may still offer value in managing patients, but further investigation is required to confirm these preliminary observations.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.