可编程释放药物的氧化还原反应降解抗菌剂,增强抗菌活性。

IF 5.4 2区 医学 Q1 BIOPHYSICS
Yue Zhang, Xuehan Yang, Yawei Zhao, Fangman Chen, Tongfei Shi, Ziping Wu, Xuenian Chen, Ming Zhang, Li Chen
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引用次数: 0

摘要

全球抗生素耐药性危机促使人们必须开发更有效的给药系统来治疗细菌感染。开发具有高生物相容性和靶向递送抗菌药物的系统仍是一项长期挑战。为了在感染部位可编程地释放高效抗菌素以增强抗菌活性,我们在本文中制备了具有高载药量的二硒化桥键介孔有机硅纳米颗粒-银纳米颗粒(Ag NPs),用于在一个给药系统(Ag-MON@TOB (Se))中联合给药妥布霉素(TOB)。制备出的 Ag-MON@TOB (Se) 在生理条件下具有高稳定性,因而具有良好的生物相容性。值得注意的是,这种Ag-MON@TOB(Se)具有可编程的结构失稳性,可根据细菌感染微环境中的氧化刺激触发药物的连续释放。与纳米载体框架内氧化稳定的二硫键分子(Ag-MON@TOB (S))不同,Ag-MON@TOB (Se)的可编程药物释放行为增强了体外和体内的抗菌治疗效果。这项工作代表了通过利用反应灵敏的可降解载体来提高细菌感染治疗效果的可编程药物释放策略的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity.

The global crisis of antibiotic resistance has impelled the exigency to develop more effective drug delivery systems for the treatment of bacterial infection. The development of possessing high biocompatibility and targeted delivery of antimicrobials remains a persisting challenge. For programmable release of efficient antimicrobials in infection sites to enhance antibacterial activity, herein, we fabricated diselenide-bridged mesoporous organosilica nanoparticle-supported silver nanoparticles (Ag NPs) with high drug-loading capacity for the co-delivery of tobramycin (TOB) within one drug delivery system (Ag-MON@TOB (Se)). The resultant Ag-MON@TOB (Se) exhibited favorable biocompatibility due to its high stability in the physiological condition. Notably, such Ag-MON@TOB (Se) manifested a programmable structural destabilization to trigger sequential drug release in response to the oxidative stimuli within the bacterial infection microenvironment. In contradistinction to the oxidation-stable disulfide bond moieties within the framework of the nanocarrier (Ag-MON@TOB (S)), the Ag-MON@TOB (Se) with its programmed drug release behavior augmented prominent antibacterial therapy both in vitro and in vivo. This work represents a promising strategy for programmable drug release by harnessing a responsive degradable vehicle to enhance the treatment of bacterial infection.

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来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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