口服纳米颗粒在胃肠道中的转运研究进展。

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI:10.1016/j.colsurfb.2024.114321

Tingting Song, Lu Yuan, Jie Wang, Wenjing Li, Yong Sun

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引用次数: 0

摘要

胃肠道（GIT）中的生物屏障阻碍了不溶性药物的口服吸收。最近，旨在提高口服药物疗效的各种纳米颗粒（NPs）的开发取得了重大进展。然而，NPs 细胞内转运的机制仍不清楚，在提高药物口服生物利用度方面仍存在局限性。本文回顾了口服 NPs 吸收所面临的挑战，提出了克服这些障碍的策略，并探讨了未来的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in the transport of oral nanoparticles in gastrointestinal tract.

Biological barriers in the gastrointestinal tract (GIT) prevent oral absorption of insoluble drugs. Recently, significant progress has been made in the development of various nanoparticles (NPs) designed to enhance the efficacy of oral drugs. However, the mechanism underlying the intracellular transport of NPs remains unclear, and there are still limitations to improving the oral bioavailability of drugs. This article reviews the challenges faced in the absorption of oral NPs, proposes strategies to overcome these barriers, and discusses the future prospects.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.