基于蚕丝纤维的生物电子器件,用于高灵敏度、稳定和长时间的体内记录。

IF 10.7 1区 生物学 Q1 BIOPHYSICS
Biosensors and Bioelectronics Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI:10.1016/j.bios.2024.116853
Huiran Yang, Ziyi Zhu, Siyuan Ni, Xueying Wang, Yanyan Nie, Chen Tao, Dujuan Zou, Wanqi Jiang, Ying Zhao, Zhitao Zhou, Liuyang Sun, Meng Li, Tiger H Tao, Keyin Liu, Xiaoling Wei
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引用次数: 0

摘要

蚕丝纤维素具有公认的生物相容性和可修改特性,在生物电子学方面具有巨大潜力。然而,由于蚕丝纤维素的高吸水性,传统的蚕丝生物电子器件在水环境或体内环境中会迅速丧失功能,导致膨胀、结构损坏和导电失效。在这项研究中,我们开发了一种新方法,通过对蚕丝蛋白进行物理改性,制造出定向结晶(OC)蚕丝纤维蛋白。这一进步使我们能够制造用于慢性生物电位记录的电子界面。通过对丝膜进行预拉伸处理,可以实现可调的分子取向和结晶,从而显著增强其水溶性、生物相容性和电子屏蔽能力。OC 设备在皮肤电信号的灵敏检测和运动跟踪、高信噪比(SNR >20)的活体小鼠肌电信号长期(超过七天)采集以及癫痫模型(200-500 Hz)的高频振荡(HFO)精确检测方面表现出了强大的性能。这项工作不仅提高了蚕丝纤维蛋白的结构和功能完整性,还扩展了其在耐用生物电子学和适合长期生理环境的界面中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Silk fibroin-based bioelectronic devices for high-sensitivity, stable, and prolonged in vivo recording.

Silk fibroin, recognized for its biocompatibility and modifiable properties, has significant potential in bioelectronics. Traditional silk bioelectronic devices, however, face rapid functional losses in aqueous or in vivo environments due to high water absorption of silk fibroin, which leads to expansion, structural damage, and conductive failure. In this study, we developed a novel approach by creating oriented crystallization (OC) silk fibroin through physical modification of the silk protein. This advancement enabled the fabrication of electronic interfaces for chronic biopotential recording. A pre-stretching treatment of the silk membrane allowed for tunable molecular orientation and crystallization, markedly enhancing its aqueous stability, biocompatibility, and electronic shielding capabilities. The OC devices demonstrated robust performance in sensitive detection and motion tracking of cutaneous electrical signals, long-term (over seven days) electromyographic signal acquisition in live mice with high signal-to-noise ratio (SNR >20), and accurate detection of high-frequency oscillations (HFO) in epileptic models (200-500 Hz). This work not only improves the structural and functional integrity of silk fibroin but also extends its application in durable bioelectronics and interfaces suited for long-term physiological environments.

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来源期刊
Biosensors and Bioelectronics
Biosensors and Bioelectronics 工程技术-电化学
CiteScore
20.80
自引率
7.10%
发文量
1006
审稿时长
29 days
期刊介绍: Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.
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