Chalcogenised Fe3Se2(CO)9 Cluster 催化二茂铁醛与胺的氧化氨化反应：醛到酰胺的直接转化。

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-10-14 DOI:10.1002/asia.202400996

Deepak Sharma, Aditya Choudhary, Vijesh Tomar, Raj K Joshi

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引用次数: 0

摘要

由于对二茂铁共轭物的兴趣和了解其重要性，我们在可行的条件下开发了二茂铁醛的直接酰胺化反应。各种胺与二茂铁醛在高度经济和稳定的铬化铁碳酰簇[Fe3E2(CO)9，E= S、Se 和 Te]和 TBHP 的存在下进行了氧化偶联。该反应在 70 °C 的适中温度下，在更环保的水溶剂中进行，只需 30 分钟就能合成二茂铁酰胺。由于二茂铁基酰胺具有很高的药用价值，本报告的唯一重点是合成各种新的二茂铁基酰胺，其含量从优到良。

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Oxidative Amidation of Ferrocenyl Aldehydes with Amines Catalyzed by Chalcogenised Fe₃Se₂(CO)₉ Cluster: Direct Transformation of Aldehyde to Amides.

With the interest and knowing the importance of ferrocenyl conjugates, a direct amidation of ferrocenyl aldehyde has been developed under feasible conditions. Varieties of amines has been oxidatively coupled with ferrocene aldehyde in the presence of highly economical and robustly stable iron chalcogenide ironcarbonyl clusters [Fe₃E₂(CO)₉, E= S, Se, and Te] and TBHP. The reaction worked in greener solvent water at a moderate temperature of 70 °C and the ferrocenyl-amides in just 30 minutes. All the varieties of amines were found to be well tolerated for the present method, and due to the high medicinal importance of ferrocenyl-amides, sole focus of this report was concentrates on the synthesis of various new ferrocenyl-amides in good to excellent amounts.

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).