罕见但相关：甲基苯丙胺与帕金森病。

IF 5.2 1区医学 Q1 PSYCHIATRY

Addiction Pub Date : 2024-10-22 DOI:10.1111/add.16695

Julia M Lappin

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引用次数: 0

摘要

来自一些范例的证据表明，吸食甲基苯丙胺与帕金森病和帕金森综合症的发病风险增加有关，而且可能与帕金森病的过早发病有关。帕金森病和帕金森氏症的发病率在甲基苯丙胺使用者和曾吸食甲基苯丙胺的人中都较高，动物研究的证据为这一观察结果提供了一个似是而非的机制。尽管风险增加，但很少诊断出甲基苯丙胺使用者患有帕金森病。造成这种情况的原因可能包括检测不足、过早死亡，以及个人和药物使用特征（包括较高的吸烟率）会降低风险。临床医生应警惕甲基苯丙胺使用者帕金森病和帕金森氏症的体征和症状。

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Rare but relevant: Methamphetamine and Parkinson's disease.

Evidence from a number of paradigms suggests that methamphetamine use is associated with increased risk for the development of Parkinson's disease and parkinsonism, and that it may be associated with the premature development of Parkinson's disease. Prevalence of Parkinson's disease and parkinsonism is greater in both methamphetamine users and people who previously used methamphetamine, and evidence from animal studies provides a plausible mechanism for this observation. Despite this increased risk, Parkinson's disease is rarely diagnosed in methamphetamine users. Reasons for this may include under-detection, premature mortality, and individual and substance use characteristics which moderate the risk, including higher rates of smoking. Clinicians should be vigilant to signs and symptoms of Parkinson's disease and parkinsonism in methamphetamine users.

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.