舍拉金木素 X 的合成和结构确认。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-17 DOI:10.1039/d4ob01529k

Tereza Havlíková, Sundaravelu Nallappan, Ivana Císařová, Lukas Rycek

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引用次数: 0

摘要

我们首次报道了天然产品 selaginpulvilin X 的全合成，这是一种 selaginellaceae 多酚类化合物。我们的合成策略采用了交叉耦合反应和有机锂加成来构建碳框架。随后，通过官能团修饰和脱保护作用得到天然产物。通过比较天然样品和合成样品，光谱分析证实了所提出的结构。

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Synthesis and structural confirmation of selaginpulvilin X.

We report the first total synthesis of the natural product selaginpulvilin X, a selaginellaceae polyphenol class of compounds. Our synthetic strategy employs cross-coupling reactions and an organolithium addition to construct the carbon framework. Subsequently, the functional group modifications and deprotection yield the natural product. Spectral analysis confirms the proposed structure by comparing natural and synthetic samples.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464