钯催化芳基羧酸 2-吡啶酯与末端炔的交叉偶联。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-10 DOI:10.1039/d4ob01398k

Hang Yu , Jing-Jing Nie , Zhong-Xia Wang

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引用次数: 0

摘要

在 Na2CO3 的存在下，PdCl2(dppf)、dppp 和 CuI 可催化芳基羧酸 2-吡啶酯与末端炔烃的脱羰基偶联反应，生成 1,2-二取代炔烃。(异)芳基、烷基和硅基乙炔以及各种供电子和吸电子基团取代的芳基羧酸 2-吡啶酯均可用于这种转化，并显示出一系列官能团的兼容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-catalyzed cross-coupling of arylcarboxylic acid 2-pyridyl esters with terminal alkynes†

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Palladium-catalyzed cross-coupling of arylcarboxylic acid 2-pyridyl esters with terminal alkynes†

In the presence of Na₂CO₃, the combination of PdCl₂(dppf), dppp and CuI catalyzes the decarbonylative coupling of arylcarboxylic acid 2-pyridyl esters with terminal alkynes to afford 1,2-disubstituted acetylenes. (Hetero)aryl, alkyl, and silylacetylenes and various electron-donating and -withdrawing group-substituted arylcarboxylic acid 2-pyridyl esters can be used in this transformation, with a range of functional groups showing compatibility.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.