内生链霉菌:一种尚未充分开发的来源,具有发现和开发新型天然药物的潜力

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Periyasamy Sivalingam, Maheswaran Easwaran, Dhanraj Ganapathy, S. Farook Basha, John Poté
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引用次数: 0

摘要

长期以来,链霉菌一直被认为是发现医药和农业领域天然化合物的关键来源。这些化合物已被证明具有不同的生物活性,包括抗生素、抗真菌、抗癌和抗病毒作用。因此,新的药物和抗生素应运而生。然而,在过去几十年中,从自然栖息地的链霉菌中发现的生物活性化合物寥寥无几。因此,现在人们开始重新寻找新的链霉菌物种,这些物种有可能在开发较少的自然栖息地中从一个菌株中产生多种化合物,从而有助于对抗疾病。因此,必须采用现代基因组挖掘方法,从尚未开发的资源中发现结构新颖、具有治疗用途的天然化合物。鉴于这些事实,植物内生链霉菌可能为发现具有独特化学特性和活性的生物活性化合物提供了新的途径。在本综述中,我们介绍了从植物内生链霉菌中分离天然化合物所取得的进展,这些化合物具有显著的抗菌、细胞毒性和抗真菌特性。据报道,内生链霉菌中含有不同结构类别的化合物,如吲哚半萜、大环内酯类、黄酮类、肽类、萘醌类和萜类化合物。此外,我们还讨论了现代基因组学在发现编码化合物的生物合成基因簇(BGCs)方面取得的进展。总之,这篇综述可能会为未来从尚未开发的内生链霉菌中发现新药的潜力提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Endophytic Streptomyces: an underexplored source with potential for novel natural drug discovery and development

Endophytic Streptomyces: an underexplored source with potential for novel natural drug discovery and development

Streptomyces has long been considered as key sources for natural compounds discovery in medicine and agriculture. These compounds have been demonstrated to possess different biological activities, including antibiotic, antifungal, anticancer, and antiviral effects. As a result, new pharmaceuticals and antibiotics have been developed. Nevertheless, there have been only a few novel discoveries of bioactive compounds in the past decades from Streptomyces in natural habitats. There is, therefore, now a renewed search for new Streptomyces species having the potential to produce many compounds from one strain in lesser explored natural habitats that may be helpful in fighting diseases. Consequently, modern genome mining approaches are imperative for discovering structurally novel natural compounds with therapeutic applications from untapped sources. In light of these facts, endophytic Streptomyces from plants may offer new avenues for the discovery of bioactive compounds with distinctive chemical properties and activities. In the present review, we present the progress made in isolating natural compounds from endophytic Streptomyces originating from plants which have remarkable antimicrobial, cytotoxic, and antifungal properties. A different of distinct structural classes of compounds were reported from endophytic Streptomyces, such as indolosequiterpene, macrolides, flavones, peptides, naphthoquinones, and terpenoids. Further, we discussed modern genomics progress in finding biosynthetic gene clusters (BGCs) encoding compounds. Overall, this review might provide valuable insights into the potential for novel drug discovery from untapped endophytic Streptomyces in the future.

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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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