{"title":"限制饮食对长寿和健康的复杂影响","authors":"Claire Greenhill","doi":"10.1038/s41574-024-01051-2","DOIUrl":null,"url":null,"abstract":"<p>Calorie restriction is known to extend lifespan in a wide range of species; however, the effects are variable and findings from animal models are often not applicable to humans, as the calorie restriction regimes are generally difficult to adhere to in the real world. Now, a paper has explored the effects and underlying mechanisms of several different methods of calorie restriction and dietary restriction in a genetically diverse mouse model, including dietary patterns that can be more realistically adhered to in the general human population.</p><p>From 6 months of age, 937 female mice were randomly assigned to one of five groups: ad libitum feeding; one day per week of fasting; two consecutive days per week of fasting; 20% calorie restriction; and 40% calorie restriction. The mice were kept on the diet for the duration of their natural lives. Mice in the intermittent fasting groups demonstrated compensatory feeding after the fasting period, such that mice in the one-day fast group consumed a similar amount to the mice in the ad libitum group and mice in the two-day fast group consumed 12% less. The mice in the two calorie restriction groups received their allotment of food for the weekend on Friday afternoons, and had typically consumed it by Saturday afternoon (40% calorie restriction) or Sunday afternoon (20% calorie restriction), which resulted in weekly fasting periods. The mice were also monitored in metabolic cages at three time points: ~5, ~16 and ~26 months old.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The complex effects of dietary restriction on longevity and health\",\"authors\":\"Claire Greenhill\",\"doi\":\"10.1038/s41574-024-01051-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Calorie restriction is known to extend lifespan in a wide range of species; however, the effects are variable and findings from animal models are often not applicable to humans, as the calorie restriction regimes are generally difficult to adhere to in the real world. Now, a paper has explored the effects and underlying mechanisms of several different methods of calorie restriction and dietary restriction in a genetically diverse mouse model, including dietary patterns that can be more realistically adhered to in the general human population.</p><p>From 6 months of age, 937 female mice were randomly assigned to one of five groups: ad libitum feeding; one day per week of fasting; two consecutive days per week of fasting; 20% calorie restriction; and 40% calorie restriction. The mice were kept on the diet for the duration of their natural lives. Mice in the intermittent fasting groups demonstrated compensatory feeding after the fasting period, such that mice in the one-day fast group consumed a similar amount to the mice in the ad libitum group and mice in the two-day fast group consumed 12% less. The mice in the two calorie restriction groups received their allotment of food for the weekend on Friday afternoons, and had typically consumed it by Saturday afternoon (40% calorie restriction) or Sunday afternoon (20% calorie restriction), which resulted in weekly fasting periods. The mice were also monitored in metabolic cages at three time points: ~5, ~16 and ~26 months old.</p>\",\"PeriodicalId\":18916,\"journal\":{\"name\":\"Nature Reviews Endocrinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":31.0000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41574-024-01051-2\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41574-024-01051-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The complex effects of dietary restriction on longevity and health
Calorie restriction is known to extend lifespan in a wide range of species; however, the effects are variable and findings from animal models are often not applicable to humans, as the calorie restriction regimes are generally difficult to adhere to in the real world. Now, a paper has explored the effects and underlying mechanisms of several different methods of calorie restriction and dietary restriction in a genetically diverse mouse model, including dietary patterns that can be more realistically adhered to in the general human population.
From 6 months of age, 937 female mice were randomly assigned to one of five groups: ad libitum feeding; one day per week of fasting; two consecutive days per week of fasting; 20% calorie restriction; and 40% calorie restriction. The mice were kept on the diet for the duration of their natural lives. Mice in the intermittent fasting groups demonstrated compensatory feeding after the fasting period, such that mice in the one-day fast group consumed a similar amount to the mice in the ad libitum group and mice in the two-day fast group consumed 12% less. The mice in the two calorie restriction groups received their allotment of food for the weekend on Friday afternoons, and had typically consumed it by Saturday afternoon (40% calorie restriction) or Sunday afternoon (20% calorie restriction), which resulted in weekly fasting periods. The mice were also monitored in metabolic cages at three time points: ~5, ~16 and ~26 months old.
期刊介绍:
Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.