阿尔茨海默病神经成像计划中的动脉自旋标记灌注磁共振成像：过去、现在和未来

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-21 DOI:10.1002/alz.14310

Pamela Thropp, Eliana Phillips, Youngkyoo Jung, David L. Thomas, Duygu Tosun

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引用次数: 0

摘要

在阿尔茨海默病神经成像计划（ADNI）20 周年之际，本文全面概述了动脉自旋标记（ASL）磁共振成像（MRI）在了解衰老大脑灌注变化以及与阿尔茨海默病（AD）病理生理学及其并发症的关系方面的作用。我们总结了以前使用的采集方案、现有数据以及在最新的 ADNI MRI 方案（ADNI 4）中采用多标记后延迟 (PLD) 采集方案的动机。我们还详细介绍了在不同扫描仪上设置该方案的过程，强调了 ASL 成像在未来 AD 研究中的潜力。

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Arterial spin labeling perfusion MRI in the Alzheimer's Disease Neuroimaging Initiative: Past, present, and future

On the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative (ADNI), this paper provides a comprehensive overview of the role of arterial spin labeling (ASL) magnetic resonance imaging (MRI) in understanding perfusion changes in the aging brain and the relationship with Alzheimer's disease (AD) pathophysiology and its comorbid conditions. We summarize previously used acquisition protocols, available data, and the motivation for adopting a multi-post-labeling delay (PLD) acquisition scheme in the latest ADNI MRI protocol (ADNI 4). We also detail the process of setting up this scheme on different scanners, emphasizing the potential of ASL imaging in future AD research.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.