Xianglin Dai, Tianze Li, Peng Wei, Yingying Xu, Chenxinyan Jiang, Xuyue Zhang, Xianhua Zhang, Lan Liao, Xiaolei Wang
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引用次数: 0
摘要
手术部位感染和骨结合不足是口腔种植手术的显著风险因素。本研究提出了开发钛表面极化钙钛矿(CT-P)涂层来解决这些问题。涂层产生的电刺激(ES)可抑制促炎性 M1 型巨噬细胞极化,促进抗炎性 M2 型巨噬细胞极化,从而产生有利的骨免疫调节作用。涂层产生的 ES 能与骨修复过程中会发生变化的生理电位相匹配,从而促进体内的骨结合。此外,该系统还能实现按需抗菌,这主要取决于 CT-P 涂层对超声波(US)照射的响应,从而产生活性氧(ROS)并清除植入体表面的金黄色葡萄球菌(S. aureus)。总之,这项研究为高效电活性涂层的开发和临床应用提供了宝贵的见解,也为选择性治疗手术区细菌感染提供了新的解决方案。
Time-Dependent Electrical Active and Ultrasound-Responsive Calcium Titanate Implant Coating with Immunomodulation, Osteogenesis, and Customized Antibacterial Activity
Surgical site infection and insufficient osseointegration are notable risks factors associated with oral implant surgery. In this study, the development of a polarized calcium titanate (CT-P) coating for titanium surfaces is proposed as a solution to these problems. The coating generated electrical stimulation (ES) can inhibit pro-inflammatory M1-type macrophage polarization and promote anti-inflammatory M2-type macrophage polarization, resulting in favorable bone immunomodulation. The ES generated by the coating can match the physiological electrical potential that will change during bone repair, thereby promoting osseointegration in vivo. In addition, the system can also achieve on-demand antibacterial activity, mainly depending on the CT-P coating responding to ultrasound (US) irradiation to produce reactive oxygen species (ROS) and remove Staphylococcus aureus (S. aureus) on the surface of the implant. In conclusion, this work provides valuable insights for the development and clinical application of highly efficient electroactive coatings, as well as novel solutions for the selective treatment of bacterial infections in the surgical area.
期刊介绍:
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.