我们所有人研究计划》中干眼症与心理健康状况之间的关联。

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2024-10-17 DOI:10.1016/j.ajo.2024.10.009

AARON T. ZHAO , JOCELYN HE , YUQING LEI , YONG CHEN , GUI-SHUANG YING

{"title":"我们所有人研究计划》中干眼症与心理健康状况之间的关联。","authors":"AARON T. ZHAO , JOCELYN HE , YUQING LEI , YONG CHEN , GUI-SHUANG YING","doi":"10.1016/j.ajo.2024.10.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Methods</h3><div>We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).</div></div><div><h3>Results</h3><div>Participants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; <em>P</em> < .001), anxiety disorders (34.8% vs. 14.7%; <em>P</em> < .001), bipolar disorder (5.5% vs. 2.3%; <em>P</em> < .001), and schizophrenia spectrum disorders (2.3% vs. 0.9%; <em>P</em> < .001) than controls. Adjusted for medical comorbidities (i.e., hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus), participants with DED had higher odds than controls in having a depressive disorder (odds ratio [OR]: 3.47; 95% CI: 3.32-3.62), anxiety (OR: 2.74; 95% CI: 2.63-2.85), bipolar disorder (OR: 2.23; 95% CI: 2.04-2.44), and schizophrenia spectrum disorder (OR: 2.48; 95% CI: 2.17-2.84). The association between DED and mental health conditions was stronger in Black participants than White participants (OR: 3.68 vs. 3.09, <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>Participants with DED were significantly more likely to have mental health conditions than matched participants without DED; this association was stronger in Black participants than White participants. Greater efforts should be undertaken to screen DED patients for mental health conditions, particularly in historically medically underserved populations.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"270 ","pages":"Pages 61-66"},"PeriodicalIF":4.1000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program\",\"authors\":\"AARON T. ZHAO , JOCELYN HE , YUQING LEI , YONG CHEN , GUI-SHUANG YING\",\"doi\":\"10.1016/j.ajo.2024.10.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Methods</h3><div>We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).</div></div><div><h3>Results</h3><div>Participants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; <em>P</em> < .001), anxiety disorders (34.8% vs. 14.7%; <em>P</em> < .001), bipolar disorder (5.5% vs. 2.3%; <em>P</em> < .001), and schizophrenia spectrum disorders (2.3% vs. 0.9%; <em>P</em> < .001) than controls. Adjusted for medical comorbidities (i.e., hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus), participants with DED had higher odds than controls in having a depressive disorder (odds ratio [OR]: 3.47; 95% CI: 3.32-3.62), anxiety (OR: 2.74; 95% CI: 2.63-2.85), bipolar disorder (OR: 2.23; 95% CI: 2.04-2.44), and schizophrenia spectrum disorder (OR: 2.48; 95% CI: 2.17-2.84). The association between DED and mental health conditions was stronger in Black participants than White participants (OR: 3.68 vs. 3.09, <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>Participants with DED were significantly more likely to have mental health conditions than matched participants without DED; this association was stronger in Black participants than White participants. Greater efforts should be undertaken to screen DED patients for mental health conditions, particularly in historically medically underserved populations.</div></div>\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\"270 \",\"pages\":\"Pages 61-66\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002939424004781\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002939424004781","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

设计横断面研究。方法我们利用美国国家卫生研究院的 "我们所有人研究计划 "数据库确定了 18257 名患有干眼症的参与者，他们与未患有干眼症的参与者按 1:3 的比例进行了倾向得分匹配。我们使用单变量和多变量逻辑回归模型来评估 DED 与精神健康状况（即：抑郁障碍、焦虑、双相情感障碍）之间的关联、结果患有 DED 的参与者患有抑郁症的比例明显更高（31.6% vs. 10.7%；P<0.05）。31.6%对10.7%；P<0.001）、焦虑症（34.8%对14.7%；P<0.001）、双相情感障碍（5.5%对2.3%；P<0.001）和精神分裂症谱系障碍（2.3%对0.9%；P<0.001）的患病率明显高于对照组。在对合并症（即甲状腺功能减退症、斯约格伦综合征、系统性红斑狼疮）进行调整后，DED 患者患抑郁障碍的几率高于对照组（几率比（OR）：3.47；95% CI）：3.47；95% CI：3.32-3.62）、焦虑（OR：2.74；95% CI：2.63-2.85）、双相情感障碍（OR：2.23；95% CI：2.04-2.44）和精神分裂症谱系障碍（OR：2.48；95% CI：2.17-2.84）。黑人参与者的 DED 与精神健康状况之间的关系比白人参与者更密切（OR：3.68 vs. 3.09，P<0.001）。应加大力度对 DED 患者进行精神健康状况筛查，尤其是在历史上医疗服务不足的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Associations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program

Purpose

To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.

Design

Cross-sectional study.

Methods

We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).

Results

Participants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; P < .001), anxiety disorders (34.8% vs. 14.7%; P < .001), bipolar disorder (5.5% vs. 2.3%; P < .001), and schizophrenia spectrum disorders (2.3% vs. 0.9%; P < .001) than controls. Adjusted for medical comorbidities (i.e., hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus), participants with DED had higher odds than controls in having a depressive disorder (odds ratio [OR]: 3.47; 95% CI: 3.32-3.62), anxiety (OR: 2.74; 95% CI: 2.63-2.85), bipolar disorder (OR: 2.23; 95% CI: 2.04-2.44), and schizophrenia spectrum disorder (OR: 2.48; 95% CI: 2.17-2.84). The association between DED and mental health conditions was stronger in Black participants than White participants (OR: 3.68 vs. 3.09, P < .001).

Conclusions

Participants with DED were significantly more likely to have mental health conditions than matched participants without DED; this association was stronger in Black participants than White participants. Greater efforts should be undertaken to screen DED patients for mental health conditions, particularly in historically medically underserved populations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.