耶尔森氏菌噬菌体 fMtkYen3-01 的分离和特征描述

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2024-10-19 DOI:10.1007/s00705-024-06149-6

Sophia Goladze, Sheetal Patpatia, Henni Tuomala, Matti Ylänne, Nino Gachechiladze, Daniel de Oliveira Patricio, Mikael Skurnik, Lotta-Riina Sundberg

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引用次数: 0

摘要

小肠结肠耶尔森菌引起的耶尔森菌病是欧洲第三大常见的人类肠道传染病。多种药物耐药性的出现和有效新抗生素的缺乏引起了人们对噬菌体疗法作为一种治疗选择的关注。在这里，我们报告了感染小肠结肠炎噬菌体血清型 O:3 菌株的噬菌体 fMtkYen3-01 的完整基因组序列。该噬菌体的基因组长度为 40,415 bp，GC 含量为 45.1%，有 49 个预测基因。fMtkYen3-01 感染了所测试的 42 株小肠结肠炎病毒中的 9.5%，并在 25-40 °C 和 pH 5.0-10.0 温度条件下表现出稳定性。这些结果表明这种噬菌体具有治疗潜力。

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Isolation and characterization of Yersinia phage fMtkYen3-01

Yersinia enterocolitica causes yersiniosis, the third most common gastrointestinal infection in humans throughout Europe. The emergence of multidrug resistance and the lack of effective new antibiotics have drawn attention to phage therapy as a treatment option. Here, we report the complete genome sequence of phage fMtkYen3-01, which infects Y. enterocolitica serotype O:3 strains. This phage has a genome 40,415 bp in length with 45.1% GC content and 49 predicted genes. fMtkYen3-01 infected 9.5% of the 42 Y. enterocolitica strains tested and showed stability at 25–40 °C, as well as pH 5.0–10.0. These results suggest the therapeutic potential of this phage.

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.