整合器复合体：通过靶向 RNA 聚合酶 II 参与基因表达调控的新兴复合结构

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2024-10-19 DOI:10.1007/s10142-024-01479-9

Tingyue Li, Fulei Zeng, Yang Li, Hu Li, Jiayuan Wu

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引用次数: 0

摘要

整合子复合体是一种多亚基复合体，在真核细胞中通过裂解 3' 端参与处理小核 RNA 分子。在蛋白质编码基因中，Integrator 是启动子近端暂停、释放和招募 RNA 聚合酶 II 的关键调控因子。对 Integrator 的研究表明，它在基因表达和 RNA 处理的调控中起着关键作用。Integrator 复合物的失调与包括癌症和发育障碍在内的多种人类疾病有关。因此，了解 Integrator 复合物的结构和功能对于揭示基因表达机制和开发相关疾病的潜在治疗策略至关重要。

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The Integrator complex: an emerging complex structure involved in the regulation of gene expression by targeting RNA polymerase II

The Integrator complex is a multisubunit complex that participates in the processing of small nuclear RNA molecules in eukaryotic cells by cleaving the 3’ end. In protein-coding genes, Integrator is a key regulator of promoter-proximal pausing, release, and recruitment of RNA polymerase II. Research on Integrator has revealed its critical role in the regulation of gene expression and RNA processing. Dysregulation of the Integrator complex has been implicated in a variety of human diseases including cancer and developmental disorders. Therefore, understanding the structure and function of the Integrator complex is critical to uncovering the mechanisms of gene expression and developing potential therapeutic strategies for related diseases.

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?