肿瘤转移至口腔软组织和颌骨:回顾性研究与文献综述

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Atessa Pakfetrat, Zohreh Dalirsani, Nasrollah Saghravanian, Kazem Anvari, Sajede Asalian, Armaghan Salehi, Mahboobeh Taherizadeh
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引用次数: 0

摘要

目标 转移到口腔软组织和颌骨的情况很少见,占颌面部恶性肿瘤的 1%-3%。这些病变通常发生在预后不良的广泛恶性肿瘤中。 材料与方法 研究对象为马什哈德医科大学牙科学院口腔颌面病理系和两个医院中心的存档病例。纳入标准为有病理证实的口腔转移性病变病例,无论是否确诊为原发性恶性肿瘤。 结果 在 18 名患者中发现了口腔和颌骨转移性病变,包括 7 名女性和 11 名男性,平均年龄为 49.5 岁。与其他部位相比,转移病灶更常见于颌骨(66%),尤其是下颌骨(38%)。在软组织转移病例中,牙龈的受影响程度高于其他部位。原发肿瘤最常见的部位是男性的肾脏和女性的乳房(36%-28%)。此外,在 18 个病例中,有 6 个病例(33.3%)在诊断出转移病灶后发现了其他部位的原发肿瘤。 结论 由于没有特异性体征或症状,病变的早期诊断具有挑战性,在某些病例中,病变类似于炎症、良性和反应性病变。因此,牙医在诊断这类病变方面起着至关重要的作用,因为他们可以发现隐藏的远处原发肿瘤。对于可疑病变,即使可能性很低,也应考虑进行活组织检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature

Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature

Objectives

Metastasis to the oral soft tissues and jaw is rare and accounts for 1%–3% of maxillofacial malignancies. These lesions usually occur in the context of an extensive malignant tumor with a poor prognosis.

Materials and Methods

Archived cases from the Oral and Maxillofacial Pathology Department of the Faculty of Dentistry and two hospital centers of Mashhad University of Medical Sciences were examined. Inclusion criteria were cases with available records of pathologically confirmed metastatic lesions of the oral cavity with or without diagnosed primary malignancy.

Results

Metastatic lesions in the oral cavity and jaw were found in 18 patients, including seven women and 11 men, with a mean age of 49.5 years. Metastatic lesions were more common in the jaw (66%) and particularly in the mandible (38%) than elsewhere. In the case of soft tissue metastases, the gingiva was more affected than other sites. The primary tumor was most commonly in the kidney in men and in the breast in women (36%–28%). In addition, the diagnosis of a metastatic lesion led to the detection of the primary tumor elsewhere in six out of 18 cases (33.3%).

Conclusions

Early diagnosis of the lesions is challenging, given the absence of specific signs or symptoms, which, in some cases, nonetheless resemble inflammatory, benign, reactive lesions. Therefore, dentists play a crucial role in diagnosing such lesions, as they lead to the discovery of hidden distant primary tumors. Biopsy should always be considered for suspicious lesions, even if the probability is very low.

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来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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