男性雄激素性脱发患者枕部头皮中生长期和退行期毛囊的比例:挑战既定教条

IF 3.5 3区 医学 Q1 DERMATOLOGY
Francisco Jimenez, Majid Alam
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引用次数: 0

摘要

毛囊在一生中会经历生长期(生长期)、退行期(退行期)和相对静止期(休止期)。毛囊在每个阶段所经历的时间对于决定其生成的毛发纤维的长度至关重要。这方面的干扰可表现为各种毛发疾病,如生长期脱发或急性和慢性毛发休止期脱发。长期以来,在考虑每个阶段有多少毛囊时,既定的 "教条 "是大多数毛囊处于生长期(85%-90%),其次是毛干期(10%-15%)和衰退期(1%-2%)。这些数值是根据使用不同方法(如拔毛、光电图和组织学)进行的各种研究得出的。然而,这些方法在区分毛囊休止期和生长期时都存在缺陷。我们试图通过对 14 名白种男性在常规植发手术中从枕部头皮取出的数百个毛囊进行体外立体显微镜检查,来确定毛囊的生长期和休止期比例。通过这种方法,我们发现在所有接受评估的患者中,生长期毛囊的比例(7.5%)高于休止期毛囊的比例(3.5%),这与另一个研究小组的类似观察结果一致。因此,我们认为催生毛囊的比例明显被低估了,从而对当前的既定理论提出了挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

The hair follicle can cycle throughout a lifetime, undergoing periods of growth (anagen), regression (catagen) and relative quiescence (telogen). The time that a hair follicle spends in each of these stages is crucial to determine the length of hair fibre that it produces. Perturbations in this regard can manifest in various hair diseases such as anagen effluvium, or acute and chronic telogen effluvium. The established ‘dogma’ when considering how many hair follicles there are in each stage has long been that the majority are in anagen (85%–90%), followed by telogen (10%–15%) and catagen (1%–2%). These values are based on various studies using different methodologies such as hair plucking, phototrichograms and histology. However, these methods have flaws when it comes to differentiating between catagen and telogen follicles. We sought to determine the catagen: telogen ratio through the ex vivo stereomicroscopic examination of hundreds of hair follicles removed from the occipital scalp of 14 Caucasian males during routine hair transplantation procedures. Using this methodology, and in agreement with a similar observation by another research group, we found that the percentage of catagen hair follicles was higher (7.5%) than telogen (3.5%) in all patients assessed. Consequently, we believe that the percentage of catagen follicles is clearly underestimated and therefore challenge the current established dogma.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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