P4-ATP 酶缺失对膜不对称和疾病发展的影响

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2024-10-18 DOI:10.1002/cbf.70004

Xinyu Li, Shuzhen Li, Weipu Zhang, Qi Wang, Wei Zou

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引用次数: 0

摘要

磷脂在细胞膜上呈不对称分布。P4-ATP 酶是 IV 型脂质翻转酶，负责建立和维持这种磷脂成分的不对称性。重要的 β 亚基 CDC50（又称 TMEM30）有助于 P4-ATP 酶的运输和正常运作。P4-ATP 酶及其 β 亚基的缺失会破坏膜的不对称性，影响生长和发育，并导致影响神经、骨骼肌、消化和造血系统的各种疾病。这篇综述讨论了 P4-ATP 酶及其 β 亚基在酿酒酵母、拟南芥、秀丽隐杆线虫和哺乳动物中的关键作用，为未来的研究提供了宝贵的见解。

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Impacts of P4-ATPase Deletion on Membrane Asymmetry and Disease Development

Phospholipids exhibit an asymmetrical distribution on the cell membrane. P4-ATPases, type IV lipid flippases, are responsible for establishing and maintaining this phospholipid compositional asymmetry. The essential β subunit CDC50 (also known as TMEM30) assists in the transport and proper functioning of P4-ATPases. Deletion of P4-ATPases and its β subunit disrupts the membrane asymmetry, impacting the growth and development and leading to various diseases affecting the nervous, skeletal muscle, digestive, and hematopoietic systems. This review discusses the crucial roles of P4-ATPases and their β subunit in Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, and mammals, offering valuable insights for future research.

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.