噻蒽盐与芳烃：碱促进 C-N 键的构建

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-10-17 DOI:10.1002/adsc.202400889

Jinghui Lyu, Xianghao Zhang, zijin Luo, Yang Jiang, Kexue Xing, guofu Zhang, Chengrong Ding

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引用次数: 0

摘要

胺化合物广泛存在于天然产品、药品和农药中。我们提出了一种碱促进的多取代芳香胺合成方法。以芳基噻蒽盐为芳炔前体，利用取代基引起的芳基变形，实现了简单、快速、高原利用率和高区域选择性的非原位胺化反应。这种方法为有机合成提供了新的可能性。

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Thianthrenium salts to arynes: base promoted C-N bond construction

Amine compounds are widely found in natural products, pharmaceuticals, and pesticides. We propose a base-facilitated synthesis method of polysubstituted aromatic amines. A simple, rapid, plateau-utilization, and highly regioselective non-in-situ amination reaction was achieved by using aryl thianthrenium salt as the aryne precursor, and the arylynyl distortion induced by the substituents. This method provides new possibilities for organic synthesis.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.