金刚烷胺对小鼠异丙酚麻醉后的恢复、术后认知功能障碍和疼痛的影响

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-10-11 DOI:10.1016/j.bbr.2024.115290

Burçin Alaçam , Şeyma Nur Başarır , Ayça Taş Tuna , Onur Palabıyık , Hüseyin Çakıroğlu

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引用次数: 0

摘要

导言术后认知功能障碍（POCD）包括一系列术后认知障碍，归因于大脑平衡的破坏。其发病机制包括谷氨酸毒性、GABA 受体功能障碍以及 NMDA 和 AMPA 受体的改变。本研究旨在探讨麻醉前服用金刚烷胺与异丙酚联合麻醉时对术后恢复时间、POCD 和应激相关疼痛水平的影响：对照组、丙泊酚组、金刚烷胺组和金刚烷胺+丙泊酚组。根据以往文献，腹腔注射金刚烷胺和丙泊酚。结果与单独使用异丙酚相比，服用金刚烷胺能显著缩短异丙酚麻醉的恢复时间，延长痛觉时间，并保留认知功能。在莫里斯水迷宫中，接受金刚烷胺治疗组在目标象限停留的时间明显更长。讨论由于金刚烷胺对谷氨酸和 NMDA 受体的拮抗作用，其神经保护作用减轻了异丙酚对认知功能和痛觉的不利影响。结论在异丙酚麻醉前服用金刚烷胺对小鼠的术后恢复、认知功能保护和应激相关痛觉有积极影响。这些发现为减轻与手术相关的 POCD 和疼痛提供了一种潜在的治疗策略。

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The effect of Amantadine on recovery, postoperative cognitive dysfunction and pain after propofol anesthesia in mice

Introduction

Postoperative cognitive dysfunction (POCD) encompasses a spectrum of cognitive impairments following surgery, attributed to disruptions in brain homeostasis. The pathogenesis involves glutamate toxicity, GABA receptor dysfunction, and alterations in NMDA and AMPA receptors. This study aimed to investigate the impact of pre-anesthetic amantadine administration on postoperative recovery time, POCD, and stress-related pain levels when combined with propofol anesthesia.

Methods

Twenty-four adult male BALB/C mice were divided into four groups: Control, Propofol, Amantadine, and Amantadine+Propofol. Amantadine and propofol doses were administered intraperitoneally based on previous literature. Recovery time, pain levels (assessed via tail pinch and hot plate tests), cognitive functions (evaluated through Morris Water Maze), and locomotor activity (measured via Open Field Test) were recorded.

Results

Amantadine administration significantly reduced recovery time from propofol anesthesia, prolonged pain perception, and preserved cognitive functions compared to propofol alone. The time spent in the target quadrant in the Morris Water Maze was significantly longer in groups receiving amantadine. Additionally, the distance covered until finding the platform was significantly shorter in the propofol-only group.

Discussion

Amantadine's neuroprotective effects, attributed to its antagonistic action on glutamate and NMDA receptors, mitigate the detrimental effects of propofol on cognitive function and pain perception. This study highlights the potential of combining amantadine with propofol to enhance postoperative outcomes.

Conclusion

Amantadine administration before propofol anesthesia positively influenced postoperative recovery, cognitive function preservation, and stress-related pain perception in mice. These findings suggest a potential therapeutic strategy to mitigate POCD and pain associated with surgery.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.